genetic testing and adverse selection l.
Skip this Video
Loading SlideShow in 5 Seconds..
Genetic Testing and Adverse Selection PowerPoint Presentation
Download Presentation
Genetic Testing and Adverse Selection

Loading in 2 Seconds...

play fullscreen
1 / 25

Genetic Testing and Adverse Selection - PowerPoint PPT Presentation

Download Presentation
Genetic Testing and Adverse Selection
An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.

- - - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript

  1. Genetic Testing and Adverse Selection Richard D. MacMinn Illinois State University and Patrick L. Brockett University of Texas

  2. The initial planning process culminated in 1990 with the publication of a joint research plan, "Understanding Our Genetic Inheritance: The U.S. Human Genome Project. The First Five Years FY 1991-1995“ and the 15 year Human Genome Project Began 26 June 2000- International Human Genome Sequencing Consortium Announces the Working Draft of the Human Genome 15 February 2001 - Complete human genome sequence announced in the two leading scientific journals - Nature(NIH/DOE) and Science(Celera) Timeline

  3. Genome Database

  4. Quotes • “Genetic testing has the potential to revolutionize medicine. But revolutions can have casualties.” • Francis Collins, Director of the Human Genome Project, Newsweek, 1996 • “All progress is precarious, and the solution of one problem brings us face to face with another problem.” • Martin Luther King

  5. Concerns:Should regulators care? • Should insurers be able to underwrite using the results of genetic tests? Under what conditions? • Concern about discrimination creating a class of uninsured risks • Will there be a repeat of the industry exit such as occurred in Washington DC?

  6. Why should insurers care?

  7. Why should regulators care? • A Texas woman who was turned down for life and disability insurance because her doctor had noted on records that her mother might have died of Huntington's disease. Her mother, however, had never been diagnosed.

  8. Fear of losing insurance • In April 1996 two US Marines were court-marshaled and ultimately discharged from the Marines for refusing to provide a DNA sample. The Marines feared that information might leak from the government storehouse and others might eventually be able get access to their genetic sample. They feared that they could experience genetic based discrimination in employment or health insurance after they left the Marines.

  9. Example: "discriminating" based on genetic information • A California man was denied health insurance when he changed jobs because he had the gene for neurofibromatosis, even though he no signs of the disease.

  10. Fear of losing employment • Burlington Northern & Santa Fe Railway • In a case that sends a strong signal discouraging employers' use of genetic testing, Burlington Northern & Santa Fe Railway Co. agreed to pay $2.2 million to 36 employees to settle a landmark Equal Employment Opportunity Commission lawsuit over the controversial screening.

  11. Regulation • United Kingdom • Europe • United States • Asia

  12. United Kingdom • Previously industry was regulated by the ABI code of conduct • According to the code, insurers could not require genetic tests. • Now there is a five year moratorium • “…from 1 November 2001 insurers will not take genetic data into consideration when evaluating premiums unless the government's Genetics and Insurance Committee has approved the test and the policy is a life policy exceeding £500,000 or another policy, for example long-term care cover, exceeding £300,000.” • “So far, the only test the committee has approved is for Huntington's disease, but it is also in the process of reviewing whether tests for a hereditary form of Alzheimer's disease, as well as breast and ovarian cancer, can be included.”

  13. Europe • Council of Europe • Convention on Human Rights and Biomedicine (1997) • Chapter IV – Human genome • Article 11 – Non-discrimination - Any form of discrimination against a person on grounds of his or her genetic heritage is prohibited. • Article 12 – Predictive genetic tests - Tests which are predictive of genetic diseases or which serve either to identify the subject as a carrier of a gene responsible for a disease or to detect a genetic predisposition or susceptibility to a disease may be performed only for health purposes or for scientific research linked to health purposes, and subject to appropriate genetic counselling.

  14. Europe • Legislation prohibiting access • Austria (The Gene Technology Act, 1994) • Belgium (Law on Terrestrial Insurance Contracts, 1992) • Norway (Act Relating to the Application of Biotechnology in Medicine, Law n. 56 of 5 August 1994) • Sweden (Law 114 of March 1991 on the Use of Certain Gene Technologies within the Context of General Medical Examinations (1993))

  15. Europe • Moratorium prohibiting access • France (French Federation of Insurance Companies, 1994, 1999) • Germany (German Insurers’ Association, 1999) • The Netherlands (Verzekeraars verlengen moratorium erfelijkheidsonderzoek, December 1990 (1995)) • Switzerland

  16. Europe • Voluntary code • Finland, Greece, Ireland • Other • Italy, Portugal

  17. Asia • China • Almost unanimously - by 91% - the scientists said that couples who carried the same disease-causing genetic mutation should not be allowed to have children.

  18. United States - Health • Early regulation in 1975, 1978, 1982 prohibited denial of health coverage or charging higher premiums for those with the sickle cell trait. • 40 of the 50 states have regulations covering genetic testing. • The regulations generally prohibit cancelling, limiting, denying or establishing differentials in premium rates based on genetic test results • California, New Hampshire and New Jersey prohibit the use of family history in setting rates • Concerns • Can self-insuring employers limit coverage? Yes • Can employer see results of genetic tests? Yes

  19. United States - Life • Existing state law on life insurance can be categorized as follows: • (1) those that require that life insurers obtain the applicants’ informed consent for genetic testing or use of genetic information, e.g., AZ, CA, MA, MN; • (2) those that require that life insurers use genetic information only in an actuarially justified manner, e.g., MT, NJ, NM; and • (3) proposals to prohibit the use of genetic information altogether or for policies below a certain dollar amount, e.g., AZ, CA, NY, Oregon.

  20. Adverse Selection • Literature • MacDonald, NAAJ, 1999 • Subramanian, et. al., JRI, 1999 • Lemaire, et. al., NAAJ, 2000 • Boyer • To insure or not insure • Pooling • Separating

  21. Adverse Selection • Market Equilibria • Life • Health • Demand • Supply • Equilibria

  22. Demand

  23. Equilibrium

  24. Concluding Remarks • Is there concern of adverse selection in the insurance industry? -- yes -- “death spiral” concerns -- Are they exaggerated -- possibly • Is there a need for regulatory oversight? -- possibly, with restraint and rational approaches that respect market economics

  25. Precautionary Quote • "Our society went into the age of nuclear energy blindly, and we went into the age of DDT and other pesticides blindly. But we cannot afford to go into the age of genetic engineering blindly. Instead we must move into this exciting new era with an awareness that gene therapy can be used for evil as well as for good. As we reap the benefits of this technology, we must remember its pitfalls and remain vigilant." • W. French Anderson, Scientific American, 1995