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  1. Issues in Biotechnology: The Way We Work With Life Dr. Albert P. Kausch lifeedu.org OnCampus Live BCH 190, MIC 190, AFS 190, NRS 190, PLS 190 OnLine BCH 190 A Sweeping General Survey on Life and Biotechnology A Public Access College Course The University of Rhode Island Issues in Biotechnology: Biotechnology, Our Society and Our Future

  2. Issues in Biotechnology: The Way We Work With Life Dr. Albert Kausch Kimberly Nelson BCH 190 Section I. The Mechanics of DNA: What is Life? Section II. The Applications of Biotechnology A Sweeping General Survey on Life and Biotechnology A Public Access College Course The University of Rhode Island lifeedu.org

  3. Issues in Biotechnology: The Way We Work With Life Dr. Albert Kausch Kimberly Nelson BCH 190 The Mechanics of DNA: What is Life? Introduction and Overview- Biotechnology: Panacea or Pandora’s Box Setting the Stage: What is Science? Lectures 1 & 2 lifeedu.org

  4. Issues in Biotechnology: The Way We Work With Life Dr. Albert P. Kausch lifeedu.org The Mechanics of DNA: What is Life? Setting the Stage: What is Science? A Sweeping General Survey on Life and Biotechnology The University of Rhode Island Setting the Stage: What is Science? Lectures 2

  5. Issues in Biotechnology Professor Dr. Albert P. Kausch, Ph.D. Department of Cell and Molecular Biology University of Rhode Island Office, Lab, and Mailing Address Food Science and Nutrition Building 530 Liberty Lane, Rm 108 West Kingston, RI 02892 Office Telephone 401-874-7121 Email: kauschlaboratory@gmail.com Office hours Weds. 12:00- 3:00 pm

  6. Issues in Biotechnology Course Requirements Course Syllabus and Description Schedule of Lectures Requirements and Deliverables Office Hours

  7. Issues in Biotechnology Course Requirements Texts Jay Phelen What is Life? A guide to biology. Freeman Press. 2010 Icliker devices will be provided Course Presentations: Attendance is absolutely mandatory. Your final grade will be downgraded by half a letter grade for any unexcused absence or missed lecture (or any part of one class). You will receive a zero for the missed weekly quiz without a make-up. If you must be absent, you MUST notify Dr. Albert Kausch and provide documentation for your absence. Attendance will be determined using the iclicker technology and participation in the weekly quizzes. There will be no make up tests or exams without appropriate and express written permission. Missing class and quizzes will drastically affect your grade.

  8. Issues in Biotechnology Course Requirements Quizzes (weekly) will be taken in class (Live version on Campus) or OnLine (BCH 190 OnLine version) and promptly graded. The quizzes cover: the assigned reading from the class text focusing on both concepts and vocabulary, and concepts from the weekly live lecture(s). These quizzes consist of 20 multiple choice questions and function as a test of general knowledge on the subject. There are no make-up exams or quizzes without a medical excuse. Many quiz questions are covered during class (pay attention). In addition, many of the quiz questions are listed under the lifedu.org website in the Study Guide Section. Failure to complete a quiz or an exam will result in a zero.

  9. Issues in Biotechnology Course Requirements 2 Exams are provided and intended to be taken at the mid-term and final and will cover both class lecture material as well as the class text, up to that date (i.e. comprehensive). The exams are derived from the quiz questions (save your quizzes) Stock Project students will be responsible for a project, due before the end of term, detailing current market analysis of several publicly traded biotechnology companies. The idea is to select five biotechnology companies and invest $100,000 (fictitiously, of course). To do this look up the company and determine their ticker symbols. Look at the cost per share that the company is currently trading at and determine the number of shares that you can purchase, You can spread your money evenly across five companies (i.e. $20,000 each) or not. For example, if a company is trading at $20/share you can purchase 1,000 shares for $20, 000. You must choose your companies and shares. Toward the end of the semester you should look up these same companies and determine the cost per share at that time. Calculate your losses or gains for each company and your total losses and gains. This project will be summarized with a one page written report. This will be described in class.

  10. Issues in Biotechnology • Are you a: • New York Yankees fan • Boston Red Sox fan • New York Mets fan • Some other team • I don’t care about baseball

  11. Issues in Biotechnology • Some course demographics • You are a: • Freshman • Sophomore • Junior • Senior • Teacher

  12. Issues in Biotechnology • Are you a: • Life sciences major • Science major, but not life sciences • Non-science major • General • Undeclared

  13. Issues in Biotechnology • I know: • A lot about biotechnology • General information about the basis of biotechnology • What I read in public press • Very little actually, only about some of the arguments • Nothing at all

  14. Issues in Biotechnology • Are you a: • Republican • Democrat • Independent • Socialist • Other

  15. Issues in Biotechnology • I consider myself: • Religious • Somewhat religious • Secular • Somewhat secular • Irrelevant to this course

  16. Issues in Biotechnology • You are: • Pro-choice • Pro-life • Undecided • I don’t care about politics • Circumstantial

  17. What is Life? What is Life?

  18. What is Life? What is Life? When did it start on earth? Where did it come from? Biologically, what is it? How does it happen? How do we understand life from its mechanisms? What are the philosophical implications?

  19. What is Life? What is Life? What are we doing here? Who are you? What is consciousness? Is there really free will? It it just a biological construct?

  20. What is Life? What is Life? Is there intrinsic meaning or is it all merely biological? What is purpose? Is there a purpose to the way things develop? Is there meaning? And, what about God?

  21. Issues in Biotechnology • I can tell when someone is watching me from behind: • Yes • No • Sometimes

  22. Science is a system of hypothesis making and testing Is Evidence Based Do Not Believe what you here only

  23. What Is Life? A Guide To Biology • By J. Phelan This week: Reading Assignment: CHAPTER 1 Scientific Thinking What is it? Think Critically

  24. Biotechnology and Society What should we believe?

  25. Why do you believe what you believe?

  26. Fact n. 1. Something known with certainty. 2. Something asserted as certain. 3. Something that has been objectively verified by observation or evidence. 4. Something having real demonstrable existence.

  27. Belief n. 1. The mental act, condition or habit of placing trust or confidence in a person or thing; faith. 2. mental acceptance or conviction in the truth or actuality of something. 3. Something believed or accepted as true-see synonyms at opinion

  28. Knowledge: n. 1. The state or fact of knowing. 2. Familiarity, awareness, or understanding gained through experience or study. 3. That which is known; the sum or range of what has been perceived, discovered or inferred. 4. Learning. 5. Specific information about something. 6. Carnal knowledge.

  29. Theory,pronunciation: \ˈthē-ə-rē, ˈthir-ē\ , function: noun, inflected Form(s): plural the·o·ries, etymology: Late Latin theoria, from Greek theōria, from theōrein Date: 1592 1 : the analysis of a set of facts in their relation to one another2 : the general or abstract principles of a body of facts, from science, or study of an art as in <music theory>3 : a plausible or scientifically acceptable general principle or body of principles offered to explain phenomena <the wave theory of light> 4a : a belief, policy, or procedure proposed or followed as the basis of action <her method is based on the theory that all children want to learn> b : an ideal or hypothetical set of facts, principles, or circumstances —often used in the phrase in theory<in theory, we have always advocated freedom for all>5a : a hypothesis assumed for the sake of argument or investigation b : an unproved assumption : conjecture c : a body of theorems presenting a concise systematic view of a subject <theory of equations> synonyms see hypothesis

  30. What is Science? What is knowledge? How do we know anything? Science is a system for knowledge acquisition conducted by hypothesis making and testing and reproducible observations… See the world! Evidence based knowledge Beliefs Truth Fact Knowledge Theory

  31. Do you believe in things you can’t see?

  32. Atoms • Elemental units of which everything is made • Atomic Diameters: one to a few hundred millionths of an inch

  33. The Periodic Table of Elements Is the Same Throughout the Universe

  34. Is water required for life? Is a carbon chemistry required for life?

  35. How Did Life on Earth Begin? How Did Life on Earth Begin?

  36. How does life work?

  37. What is Science? What is knowledge? How do we know anything? Science is a system for knowledge acquisition conducted by hypothesis making and testing and reproducible observations… See the world! Evidence based knowledge Beliefs Truth Fact Knowledge Theory

  38. We need to look at the mechanics of life

  39. 15. Observation of and wonder at the workings of nature are what initiate “why” and “how” type questions. Science is a system of: (A) relying on one’s best intuition, inspiration and perspiration to solve problems (B) advertising as a devious enterprise conceived by entrepreneurial western capitalists to make money from the ideas of inventive and often eccentric minds (C) making theories that fit certain beliefs about why and how things happen (D) hypothesis making about the mysteries of life (E) hypothesis making and testing to discern and validate observable facts generating evidence based knowledge

  40. 16. A chemical unit consisting of negatively charged electrons orbiting a positively charged nucleus is: (A) an atom (B) a eukaryotic cell (C) a molecule (D) a ribosome (E) a unit

  41. 17. Which of the following statements best describes the logic of the scientific method? (A) If I generate a testable hypothesis, tests and observations will support it (B) If my prediction is correct, it will lead to a testable hypothesis (C) If my observations are accurate, they will support my hypothesis (D) If my hypothesis is correct, I can expect certain test results (E) none of these answers are correct