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DM Dewasa

DM Dewasa. EVA DECROLI. Increased of prevalence Cronic complications ex. Diabetic Foot Problems Prevention, primer, secunder tertier. Problems. Etiology of Insulin Resistence. Weight gain Obexisity. Lipoatrophy adipokines. Circulation FFA. Insulin Resistance

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DM Dewasa

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  1. DM Dewasa EVA DECROLI

  2. Increased of prevalence • Cronic complications ex. Diabetic Foot Problems • Prevention, primer, secunder tertier Problems

  3. Etiology of Insulin Resistence Weight gain Obexisity Lipoatrophy adipokines Circulation FFA Insulin Resistance The subnormal biologic response to a given concentration of insulin Physical inactivity Genetica Aging

  4. Glucose toxicity Genetics Lipotoxicity -Cell Failure Inadequate compentation for insulin resistance and selective non-responsivoness to glucose Loss of -cell …… ? Etiology of -Cell Dysfunction Cytokines ? Amyloid accumulation

  5. The Role of Genes and the Environment Normal Environment GENES Insulin resistance Diabetes genes insulin resistance genes -cel function genes Obesity genes Diet Activity Toxins Decreased Insulin secretion Type DM

  6. Risk Factors for Type 2 Diabetes Gastational Diabetes polycystic Ovarian syndrome, and party • Genetic factors • Ethnicity • Family history Type 2 Diabetes Diet Increasing age Physical inactivity Central obesity

  7. Pathophysiology of DM Peripheral Glucose Uptake Hepatic glucose Production (HGP Blood Glucose

  8. 80% of people with type 2 diabetes thr from CVD ~ Coronary heart disease (CHD) - eg, angina, heart attack, heart failure - 2-to 4-fold increased risk ~ Cerebrovascular disease - eg, stroke, transient ischemic attacks - 2-to 4-foid increased risk ~ Peripheral vascular disease - eg. Intermittent claudication, gangrene, amputations Macrovascular Complication of Type 2 Diabetes

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