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CardioSense3D Research Initiative Overview

Learn about CardioSense3D's objectives, partnerships, technology, and research topics in cardiac modeling and clinical applications. Discover the state-of-the-art tools and collaborations involved in this impactful project. Dive into the details of diagnosis, therapy planning, and personalized approaches in cardiovascular health.

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CardioSense3D Research Initiative Overview

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  1. CardioSense3DIntroductionH. Delingette Intermediate Evaluation of the CardioSense3D Research Action

  2. Agenda of the day

  3. Introduction to CardioSense3D • Scientific Objectives and Positioning • Partnership and organization

  4. What is CardioSense3D ? • An INRIA Large Initiative Action on cardiac modeling : • Started (officially) in May 2005 • 4 ans duration (evaluated after 2 years) • Transversal to 4 INRIA project teams : • ASCLEPIOS(Medical Image Analysis and Simulation) N. Ayache • MACS (Biomechanics and Numerical Analysis) : D. Chapelle • REO (Fluid Mechanics) : J-F. Gerbeau • SISYPHE (Contrôle and Modeling) : M. Sorine • Supervisor : H. Delingette, • Co-Supervisor : M. Fernandez

  5. CardioSense3D Research Topics Diagnosis Therapy planning Personalization anatomy electro-physiology perfusion & metabolism solid mechanics blood flow Clinical applications Cardiac data Cardiac modeling

  6. Objectives • Build a patient specific heart simulator • Estimate the parameters of this model from observations of the cardiac function, • Develop clinical applications(Cardiac Resynchronisation Therapy, radiofrequency ablation,..) • . Propose models having a low number of parameters

  7. State of the art anatomy perfusion & metabolism electro-physiology blood flow solid mechanics Cardiac modeling • Computational Cardiac Models • ElectroPhysiology : Noble et al. (Oxford), S. Panfilov et al. , O. Dössel (Karlsruhe), Y. Rudy et al. (Wash. Univ. St Louis), Colli-Franzone (Univ. Pavia) • Flow-Biomechanics : C. Peskin (NYU), Quarteroni (EPFL),… • Electro-mechanics : Peter Hunter et al. (Physiome project; Auckland); Andrew McCulloch et al. (UCSD)

  8. State of the art Cardiac data • Cardiac Image Analysis(Geometrical approaches) • Elliott McVeigh et al. (JHU+NIH) • D. Rueckert et al. (Imperial College) and R. Razavi et al. (KCL + Guy’s hospital) • Magnin et al (Creatis), Duncan et al (Yale), Axel and Metaxas (Rutgers & NYU), Frangi et al. (Univ. Pompeu Fabra), P. Shi (Hongkong Univ.)

  9. State of the art Diagnosis Therapy planning • Therapy planning (Generic Models) • D. Noble (Oxford) • A. Mc Culloch (UCSD) • O. Dössel (U. Karlsruhe) & F. Sasche (U. Utah) Clinical applications

  10. Positioning of CardioSense3D • Integrate/Couple 4 physiological phenomena : Electrophysiology, Contraction/Relaxation Mechanics, Arterial Circulation, Perfusion • To propose models having a low number of parameters in order to estimate them from clinical data. • Develop clinical applications (CRT, RF Ablation) based on personalized models

  11. CardioSense3D : Academic / Clinical / Industrial Partnership • Physiology/Control • Sisyphe/Sosso,INRIA • Numerical Analysis • Macs,INRIA • Reo, INRIA • Geometrica,INRIA • Gamma, INRIA • Univ. de Nantes • Pzlen Univ. (Czech Rep.) • LIRMM (Montpellier) • Imaging/Simulation • Asclepios,INRIA • UCL / King’s College (London) • Creatis, CNRS • Clinical Sites • Guy’s Hospital (London) • NIH (Washington) • HEGP, U678 (Paris) • Hopital Henri Mondor (Créteil) • Sunnybrook Health Sciences Center • InParys, Clinique George Bizet • Hopital Bicêtre + Paris XI U. +INSERM (Paris) • Industrial Partners • Philips Research France • ELA Medical • (Siemens)

  12. First Circle Members of CS3D Two different INRIA Research Units : • Sophia-Antipolis • Rocquencourt

  13. INRIA Support • Recruitment of : • P. Moireau (Détachement X-Corps des Telecoms) in 2005 • 4 Phd Thesis : • R. Chabiniok MD (Macs) from Sep. 2007 bourse Cordi • M. Astorino (Reo) from Janvier. 2007 bourse Cordi • F. Billet (Asclepios) from Oct 2006 • R. Djafri (Sisyphe) from 2007 • 3 Engineers : • M. Alba (Macs) 2005-2006 Ingénieur Associé • E. Phe (Macs-REO) 2006-2008 Ingénieur Associé • N. Toussaint (Asclepios) : 2006-2008 Ingénieur Associé

  14. External Support • National Scholarship : • PhD of N. Zemzemi • Philips Medical Systems Paris (Suresnes): • PhD of D. Lepiller (Asclepios) • ELA Medical : • Post-doc of M. Boulakia (Reo) and Post-doc of G. Ebrard • Siemens Corporate Research • PhD of JM Peyrat • European Health eChild • PhD of T. Mansi • European RTN HaeModel • Phd of N. Diniz Dos Santos • Industrial contracts • PhD of M. Laleg and K. Djabella

  15. Software • Current Development based on 3 software packages : • LifeV (Reo) (www.lifev.org) for CFD and electrophysiology • OpenFEM (Macs) (www-rocq.inria.fr/OpenFEM/ ) for FEM continuum mechanics • Mips and MedInria (Asclepios) for medical image analysis + simple models for electrophysiology and soft tissue deformation (migration on SOFA) (www-sop.inria.fr/asclepios/software/MedINRIA/) • Software developed within CardioSense3D : • CardioViz3D (Asclepios) • Heartlab (Macs)

  16. Dissemination Activity • “Digital Heart” DVD (20mn) Auteurs scientifiques : Dominique Chapelle, Hervé Delingette, Miguel Fernandez, Philippe Moireau, Maxime Sermesant

  17. Dissemination Activity • “Digital Heart” Movie • Public release of Software (CardioViz3D) and database (DTI atlas) • Involvements in Conferences (NIH-INRIA workshop) • General Audience Articles (La Recherche, Ercim News)

  18. Dissemination Activity • “Digital Heart” DVD • Public release of Software (CardioViz3D) and database (DTI atlas) • Involvements in Conferences (ISBI’07, NIH-INRIA workshop) • General Audience Articles (La Recherche, Ercim News) • CardioSense3D seminars with Paris V university

  19. Dissemination Activity • “Digital Heart” DVD • Public release of Software (CardioViz3D) and database (DTI atlas) • Involvements in Conferences (ISBI’07, NIH-INRIA workshop) • General Audience Articles (La Recherche, Ercim News) • CardioSense3D seminars with Paris V university • Organisation of workshops (summer school) and conferences (FIMH’09 in Nice) • Apple ARTS Award

  20. Agenda of the day

  21. CardioSense3D Research Topics Diagnosis Therapy planning Personalization anatomy electro-physiology perfusion & metabolism solid mechanics blood flow Clinical applications Cardiac data Cardiac modeling

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