Process design for the production of fab fragment for therapy
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Process design for the production of Fab fragment for therapy. Group 6 Shiang -Yuan Hsieh, Yun-Hsuan Liu, Chao-Ming Yen. Antibody therapy. Bevacizumab v.s Ranibizumab. Anti- angiogenic drugs: block the formation of new blood v essels to inhibit tumor growth

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Process design for the production of fab fragment for therapy

Process design for the production of Fab fragment for therapy

Group 6

Shiang-Yuan Hsieh, Yun-Hsuan Liu, Chao-Ming Yen



Bevacizumab v s ranibizumab
Bevacizumabv.sRanibizumab

  • Anti-angiogenic drugs: block the formation of new blood vessels to inhibit tumor growth

  • By targeting and inhibiting the function of a natural protein called vascular endothelial growth factor (VEGF)

  • The whole antibody versus a antibody fragment


Antibody
Antibody

  • Also called immunoglobulins (Ig) that used by immune system.

  • Five classes of Ig: IgA, IgE, IgG, IgD, IgM.


Fragment antigen binding fab fragment
Fragment antigen binding(Fab fragment)

  • A region on an antibody which binds to antigens

  • Composed of one constant and one variable domain of each of the heavy and the light chain


Why make fab fragments
Why make Fab Fragments?

  • Smaller size that can promote the efficiency of penetration of tissue section.

  • Reduce nonspecific binding that results from Fc interactions.

  • Potentially higher sensitivity in antigen.

  • Reduce the risks from immune response.

  • Production is more economical.