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Mitochondria and Respiration. General features of mitochondria Experimental systems Glucose oxidation & substrate level phosphorylation The respiratory electron transport chain Oxidative phosphorylation. A. General Features. Origins: the endosymbiotic hypothesis Structure Outer membrane

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mitochondria and respiration
Mitochondria and Respiration
  • General features of mitochondria
  • Experimental systems
  • Glucose oxidation & substrate level phosphorylation
  • The respiratory electron transport chain
  • Oxidative phosphorylation
a general features
A. General Features
  • Origins: the endosymbiotic hypothesis
  • Structure
    • Outer membrane
    • Intermembrane space
    • Inner membrane
    • Matrix
  • Posttranslational import of mitochondrial proteins from the cytoplasm
  • Mitochondrial replication
b experimental systems
B. Experimental Systems
  • Mitochondrial preparations
    • Whole cells/tissue slices
    • Intact mitochondria
    • Submitochondrial particles
    • Reconstituted protein systems
  • Methods to measure respiratory activity
    • Oxygen uptake (oximetry)
    • Difference spectroscopy
    • Dye reduction
    • ATP production
b experimental systems4
B. Experimental Systems
  • Methods to track electron movements
    • Use of different electron donors and inhibitors
    • Electron paramagnetic resonance spectroscopy
    • Nuclear magnetic resonance spectroscopy
c glucose oxidation substrate level phosphorylation
C. Glucose Oxidation & Substrate-Level Phosphorylation
  • Review of basic terms
    • Oxidation and Reduction
    • Redox Cofactors
    • ATP
  • Glycolysis
  • Acetyl CoA formation and the TCA cycle
d the respiratory electron transport chain
D. The Respiratory Electron Transport Chain
  • Overview
  • Types of electron carriers in the chain
    • Flavoproteins
    • Cytochromes
    • Ubiquinone (Coenzyme Q)
    • Iron-sulfur proteins
  • The respiratory electron chain pathway
e oxidative phosphorylation
E. Oxidative phosphorylation
  • Mitchell’s chemiosmotic model for ATP formation
  • The structure of ATP synthase
  • Conformational changes and the rotational catalysis of ATP formation
  • Other roles of the proton gradient