Bleeding Disorders. Meera Shreedhara 8/25/08 . What is it?. A bleeding disorder is an acquired or inherited tendency to bleed excessively. Mechanisms of bleeding. Vascular Integrity Platelets Clotting factors Fibrinolysis Derangement of any of these factors can cause abnormal bleeding.
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Monoclonal gammopathy of unknown significance
Chronic lymphocytic leukemia
Essential thrombocythemiaPolycythemia vera
Chronic myelogenous leukemia
Systemic lupus erythematosus
Other autoimmune diseases
Ventricular septal defect
Mitral valve prolapse
Drugs and other agents
AntibioticsAcquired von Willebrand’s disease