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Phase 2. Liver Transplantation. Treatment Naïve and Treatment Experienced. Sofosbuvir + Ribavirin in HCV Recurrence Following Liver Transplantation. Charlton MR, et al. Gastroenterology. 2014 Oct 7. [ Epub Ahead of Print]. Sofosbuvir + Ribavirin in Recurrent HCV Post Liver Transplant.

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sofosbuvir ribavirin in hcv recurrence following liver transplantation
Phase 2

Liver Transplantation

Treatment Naïve and Treatment Experienced

Sofosbuvir + Ribavirin in HCV Recurrence Following Liver Transplantation

Charlton MR, et al. Gastroenterology. 2014 Oct 7. [Epub Ahead of Print]

sofosbuvir ribavirin in recurrent hcv post liver transplant
Sofosbuvir + Ribavirin in Recurrent HCV Post Liver Transplant

Source: Charlton MR, et al. Gastroenterology. 2014 Oct 7. [Epub Ahead of Print]

sofosbuvir ribavirin in recurrent hcv post liver transplant1
Sofosbuvir + Ribavirin in Recurrent HCV Post Liver Transplant

Source: Charlton MR, et al. Gastroenterology. 2014 Oct 7. [Epub Ahead of Print]

sofosbuvir ribavirin in recurrent hcv post liver transplant design
Sofosbuvir + Ribavirin in Recurrent HCV Post Liver TransplantDesign

0

24

36

Week

SVR12

Drug DosingSofosbuvir: 400 mg once dailyRibavirin: administered in two divided daily doses (started at 400 mg/day and increased up to 1200 mg/day based on hemoglobin, creatinine clearance, and weight)

Sofosbuvir + Ribavirin

N = 40

Source: Charlton MR, et al. Gastroenterology. 2014 Oct 7. [Epub Ahead of Print]

sofosbuvir ribavirin in recurrent hcv post liver transplant results
Sofosbuvir + Ribavirin in Recurrent HCV Post Liver TransplantResults

40/40

29/40

28/40

28/40

Source: Charlton MR, et al. Gastroenterology. 2014 Oct 7. [Epub Ahead of Print]

sofosbuvir ribavirin in recurrent hcv post liver transplant adverse effects
Sofosbuvir + Ribavirin in Recurrent HCV Post Liver TransplantAdverse Effects

Source: Charlton MR, et al. Gastroenterology. 2014 Oct 7. [Epub Ahead of Print]

sofosbuvir ribavirin in recurrent hcv post liver transplant conclusions
Sofosbuvir + Ribavirin in Recurrent HCV Post Liver TransplantConclusions

Source: Charlton MR, et al. Gastroenterology. 2014 Oct 7. [Epub Ahead of Print]

slide8

This slide deck is from the University of Washington’s Hepatitis C Online and Hepatitis Web Study projects.

Hepatitis C Onlinewww.hepatitisc.uw.edu

Hepatitis Web Studyhttp://depts.washington.edu/hepstudy/

Funded by a grant from the Centers for Disease Control and Prevention.