The evolution and structural anatomy of small molecule metabolism pathways in Escherichia coli. Of Pathways and Proteins Stuart Rison and Sarah Teichmann. Questions. How are homologous proteins (enzymes) distributed in E. coli metabolism?
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Of Pathways and Proteins
Stuart Rison and Sarah Teichmann
[ ] metabolism pathways in
[ ]Retrograde evolution
An extensively studied model organism metabolism pathways in
Complete genome available
Most Small Molecule Metabolism pathways well known and empirically characterised
A manageable size
Good associated databasesWhy E. coli?
SCOP metabolism pathways inMethods
566 SMM proteins
442 proteins assigned
to 1+ families (78%)
169 PDB-D families
31 ‘sequence’ domain
200 domain families
(Assumption: duplication within pathways wherever possible.)