Diabetic Retinopathy (DR) . Ayesha S Abdullah 28.12.2012. Learning outcomes. By the end of the lecture the students would be able to; Describe the epidemiology of DR Correlate the pathogenesis of DR with the clinical presentation Identify signs of DR in a given fundus photograph
Ayesha S Abdullah
By the end of the lecture the students would be able to;
Wild S, Roglic G, Green A, Sicree R, King H. Global Prevalence of Diabetes- Estimates for the year 2000 and projections for 2030. Diabetes Care 27:1047–1053, 2004
DR is a microangiopathy resulting in
Factors responsible for occlusion
Pathogenesis of Diabetic Retinopathy
Retinal capillary non-perfusion
Retinal ischaemia & Hypoxia, ischaemia of the nerve fibres- soft exudates
Arteriovenousshunts - IRMA(intra-retinal microvascualr abnormalities), venous changes, stagnation of blood and more hypoxia
Breakdown of inner blood-retinal barrier
What is inner and outer blood-retinal barrier?
1. Mild NonproliferativeRetinopathy
Signs: MA & HE
2. Moderate NonproliferativeRetinopathy
Signs:Haemorrhages, microaneurysms, Soft exudates, IRMA
3. Severe Nonproliferative Retinopathy..
Signs: Along with microaneurysms, haemorrhages, IRMA and venous changes are also seen
4. Proliferative Retinopathy.
Signs: NVE & NVD, vitreous haemorrhage, tractional RD
Principles & modes
List the risk factors for DR
How does diabetic retinopathy cause vision loss?