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Algorithms Organization

This presentation highlights ten years of groundbreaking research in diffusion tensor imaging (DTI) and statistical shape modeling. Key advancements have addressed technical challenges such as data preprocessing, denoising, and segmentation, directly influencing our understanding of conditions like schizophrenia and autism. Using robust analysis tools, the research features volumetric tractography, user interaction for visualization, and insights into specific anatomical regions like the arcuate fasciculus. The ongoing development of software pipelines and ancient grants supports ongoing investigations into brain connectivity and structure.

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Algorithms Organization

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  1. Algorithms Organization Ross Whitaker – Utah PolinaGolland – MIT (Kayhan B.) Guido Gerig – Utah Martin Styner – UNC Allen Tannenbaum – Georgia Tech

  2. Presentations Highlights from the 10-year project Recent advances Clinical/biomedical impact

  3. Diffusion Tensor Imaging • Structure, function, connectivity, and schizophrenia • Shenton/Harvard • Potkin/Irvine • Technical challenges • Data preprocessing • Robust tools for analysis

  4. DTI Technical Development • Denoising • Basu, et al., MICCAI, 2006 • Susceptibility artifacts • Tao, et al., IPMI 2009 • Segmentation • Fletcher et al., IPMI, 2007

  5. DTI Segmentation • Volumetric tractography • Volumetric paths between ROIs • A collection of shortest paths • User interaction, visualization, GPU implementations

  6. NA-MIC DTI Analysis • Ancillary grant: Lainhart/Fletcher – DTI analysis in autism • Scientific results • Arcuatefasciculus in autism, Fletcher et al, Neuroimage, 2010. • Longitudinal Heschl'sgyrusin autism, Prigge et al., 2013. • Software pipeline • Broader impact • Cardenas et al., J Neuroimaging, 2013. (UCSF)

  7. Statistical Shape Modeling • DBPs • Shenton/Schizophrenia • Piven/Autism • MacLeod/Marrouche • Robust, general methods for shape analysis • Software • ShapeWorks

  8. Technology for Shape Analysis • Correspondence/parameterization • Hypothesis testing • Regression • Longitudinal analysis • Scientific results • Harris et al., J. of Ortho. Res., 2013 • Jones et al., J. of Ortho. Res., 2013

  9. NA-MIC Ancillary Grant • Anderson: shape analysis in hip pathoanatomy (ongoing) • Shape analysis in hip biomechanics • Diagnosis and treatment planning • Database of parameterized hip models

  10. Segmentation • DBPs • Sharp/Chen, Head and Neck Cancer • MacLeod/Marrouche, Afib • Robust tools for “difficult” segmentation problems • Low SNR • High shape variability

  11. Bayesian Formulation of LA Segmentation (DCE-MRI)

  12. LA Segmentation Results

  13. Slicer Module

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