Announcements. Exam 2 next week: 10/17, 18, and 20 . Same format as exam 1, a bit shorter. You will need a bluebook again. Answers from exam 1 will be removed from lab when exam 2 answers go up. Homework/ problem set 4 (15 pts) due next week in lab.
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Exam 2 next week: 10/17, 18, and 20. Same format as exam 1, a bit shorter. You will need a bluebook again.
Answers from exam 1 will be removed from lab when exam 2 answers go up.
Homework/ problem set 4 (15 pts) due next week in lab.
Handout for transformation lab available Monday.
Variation in structure/arrangement of chromosomes
What are criteria for genetic material?
I. Evidence that DNA is genetic material
II. DNA and RNA: Composition and Function
III. History of solving the structure of DNA
What is the genetic material?
Chromosomes contain protein and DNA - which is it?
What must genetic material do?
2. Storage of information
3. Expression of information
4. Variation by mutation - evolution
Living rough +
Killed smooth converted living rough to virulent cells
A Transforming Principle (some smooth component) is responsible.
Expected mouse to live
IIR + IIIS filtrate
Indirect evidence -DNA and RNA absorb UV Light
Tobacco Mosaic Virus
Strand has 5’-PO4
end and 3’-OH end
III. History of structure of DNA:Rosalind Franklin and Maurice Wilkins found X-ray Diffraction Evidence for DNA Double Helix
Linus Pauling and Robert Corey at Cal Tech were in the Race to Determine DNA structure
James Watson and Francis Crick Used Molecular Modeling to Deduce DNA structure
Single strand of DNA:
Complementary strand of above, usually written 5’ to 3’:
Double-stranded fragment is written:
Which DNA has higher GC content and why?
Molecular probes can “fish out”
a specific DNA from a mixture