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5.1a. Post-contrast Axial T1 Wtd MRI. 5.1b. Post-contrast Coronal T1 Wtd MRI. A 52 year-old male with corpus callosal tumor. Q1. Diagnosis Please. A 60 year-old male with known hemopoetic systemic disease. Q2. Diagnosis Please. 5.2. Post-contrast Coronal T1 Wtd MRI.

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5.1a. Post-contrast Axial T1 Wtd MRI

5.1b. Post-contrast Coronal T1 Wtd MRI

A 52 year-old male with corpus callosal tumor.

Q1. Diagnosis Please

slide2

A 60 year-old male with known hemopoetic systemic disease.

Q2. Diagnosis Please

5.2. Post-contrast Coronal T1 Wtd MRI

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A 35 year-old female with multiple cranial nerve neuropathy.

Q3. Diagnosis Please

5.3. Post-contrast Axial T1 Wtd MRI

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5.1a. Post-contrast Axial T1 Wtd MRI

5.2. Post-contrast Coronal T1 Wtd MRI

5.3. Post-contrast Axial T1 Wtd MRI

Figures 5.1 – 5.3 are produced by a hemopoetic tumor.

Diagnosis: ?

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5.1a. Post-contrast Axial T1 Wtd MRI

5.2. Post-contrast Coronal T1 Wtd MRI

5.3. Post-contrast Axial T1 Wtd MRI

Figures 5.1 – 5.3 are produced by a hemopoetic tumor.

Diagnosis: Lymphoma

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5.1a. Post-contrast Axial T1 Wtd MRI

5.1b. Post-contrast Coronal T1 Wtd MRI

Figure 5.1. Homogeneously enhancing tumor is seen involving the splenium of the corpus callosum (arrows) spreading across the midline.

Diagnosis: Primary Lymphoma of the brain

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Figure 5.2.

Diagnosis: Secondary Lymphoma with calvarial involvement (green arrow) and associated epidural tumor (yellow arrows) / scalp tumor (red arrow)

5.2. Post-contrast Coronal T1 Wtd MRI

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Figure 5.3. Linear enhancement of the cerebellar sulci (yellow arrows) and left temporal sulci (red arrow).

Diagnosis: Secondary Lymphoma with subarachnoid tumor seeding (arrows).

5.3. Post-contrast Axial T1 Wtd MRI

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Central Nervous System Lymphoma

  • Primary lymphoma of the brain is rare, accounts for less than 3.5% of primary brain tumors.
  • Non-Hodgkin’s Lymphoma, usually B-cell lymphoma.
  • Can be seen in patients with AIDS.
  • Tumor intensely enhances with contrast. Common sites of involvement include:
      • Basal ganglia/thalamus
      • Corpus Callosum
      • Periventricular white matter
  • Lymphoma responds well to chemo-radiation therapy.
  • Open or stereotactic biopsy is necessary to establish the diagnosis.
  • Complete surgical resection of the tumor is not necessary as they respond well to chemo-radiation therapy