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BNP ＆ Heart failure

Yang Guibo Kang Haili Sun Xudong Liu Kai Song wei. BNP ＆ Heart failure. 1. 2. 3. 4. Why we have to know BNP. What is the use of BNP. Summary. Contents. What is BNP. BNP. B-type/brain natriuretic peptide.

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BNP ＆ Heart failure

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  1. Yang Guibo Kang Haili Sun Xudong Liu Kai Song wei BNP ＆ Heart failure

  2. 1 2 3 4 Why we have to know BNP What is the use of BNP Summary Company Logo Contents What is BNP

  3. Company Logo BNP • B-type/brain natriuretic peptide Natriuretic peptides are a family of neurohormones that consist of ANP (atrial natriuretic peptide ), BNP, and CNP (C-type natriuretic peptide ).

  4. Company Logo • BNP is a neurohormone that is synthesized in ventricularmyocardium and released in response to increased wall stress

  5. Company Logo NPRs and signal transductionmechanisms

  6. 3 Company Logo BNP’s actions 1 2 4 Down regulating the sympathetic nervous system and the RAAS Facilitating natriuresis and diuresis decreasing Peripheral vascular resistance& increasing smooth muscle relaxation inhibit cardiac growth and hypertrophy

  7. Company Logo Where BNP affects

  8. Company Logo How BNP affects

  9. Company Logo Influences on BNP Levels Exercise causes a short- term increase in BNP levels Medications used in HF digoxin and some beta blockers appear to increase BNP concentrations diuretics,ACEI, angiotensin-II receptor blockers reduce BNP concentrations

  10. Company Logo What we found in clinic

  11. Company Logo BNP toDiagnose Heart Failure BNP levels in 321 patients presenting to the emergency room with acute dyspnea

  12. Overt CHF Indicates LV CHF abnormal and indicative in elderly patients and chronic heart failure Company Logo Diagnostic BNP Ranges 600-1,500 pg/mL >400 pg/mL 200-400 pg/mL 100-200 pg/mL

  13. Company Logo Determining Prognoses

  14. Screening BNP Prevention Monitoring Patients with HF Company Logo Other uses

  15. Company Logo A simple blood test may reduce mortality of HF • 95.6% specificity at 100 pg/mL. • 98% diagnostic accuracy in • initial studies versus all • significant variables in patients • with or without disease history. • Corrected 96% of misdiagnosis in initial studies. • Diagnostic accuracy for early- and late-stage CHF without the use of other invasive or expensive diagnostic tests.

  16. Company Logo Others

  17. BNP • neurohormone • synthesized in ventricularmyo • cardium • released in response to increased wall stress Company Logo Summary Therapy It’s a dream. There is long way to go Biomarker • Diagnosis • Prognosis • Preventing • Screening • monitoring

  18. Thank You !

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