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Risk assessment for VTE. Dr Roopen Arya King’s College Hospital. Prevention of VTE in hospitalised patients:. V. Documented mandatory risk assessment for all hospitalised patients. Why the need for risk assessment for VTE?. Identifying at-risk patient. Counselling at-risk patient.

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risk assessment for vte

Risk assessment for VTE

Dr Roopen Arya

King’s College Hospital


Prevention of VTE in hospitalised patients:


Documented mandatory risk assessment for all hospitalised patients

why the need for risk assessment for vte
Why the need for risk assessment for VTE?

Identifying at-risk patient

Counselling at-risk patient



risk assessment
Risk Assessment
  • The highest ranking safety practice was the appropriate use of prophylaxis to prevent VTE in patients at risk.

AHRQ “Making Health Safer: A Critical Analysis of Patient Safety Practices” 2001

  • We recommend that every hospital develop a formal strategy that addresses the prevention of thromboembolic complications. This should generally be in the form of a written thromboprophylaxis policy especially for high risk groups.

ACCP guidelines “ Prevention of VTE” 2004

risk assessment models
Risk assessment models
  • Group-specific (‘opt-out’)
  • Individualized (‘opt-in’)
    • Risk stratification
    • Risk scores
  • Linked to ACTION of thromboprophylaxis

VTE risk assessment

in surgical patients


Risk scoring for VTE: Kucher risk score

Kucher, N. et al. N Engl J Med 2005;352:969-977

primary end point freedom from vte
Primary end point: Freedom from VTE





Freedom from DVT or PE (%)


P < 0.001




Time (days)





Number at risk











Kucher, N. et al. N Engl J Med 2005;352:969-977


Derivation and Validation of a Prediction Tool for Venous Thromboembolism (VTE):a VERITY Registry Study

study objective
Study objective
  • to develop a multiple regression model for VTE risk, based on Kucher, and validate its performance
  • to employ the extensive VTE risk factor data recorded in a UK VTE treatment registry (VERITY)
    • VERITY enrolls patients presenting to hospital with suspected VTE

UK multi-centre observational VTE registry of

clinical management practices & patient outcomes

features of verity
Features of VERITY
  • National registry – outpatient VTE treatment
  • Full spectrum of VTE – DVT and PE
  • Records information on patients presenting with suspected and confirmed VTE
  • Expanded data on demographics, presentation, management & outcomes
  • Extensive risk factor data
statistical plan model development
Statistical plan – model development
  • As a preliminary to a formal multiple regression analysis, the effects of the 8 Kucher risk factors on VTE risk were investigated individually by univariate analysis
  • Initial findings: univariate analysis (n=5928; 32.4% with diagnosis of VTE) suggested VTE risk was not accounted for by the 8 Kucher risk factors
  • An additional 3 risk factors were added (leg paralysis, smoking, IV drug use) and also patient sex, and the model was created with these 12 factors
statistical plan model development1
Statistical plan – model development
  • The multiple logistic regression model was developed using backward stepwise regression
  • The open source statistical package ‘R’ was employed to conduct the regression analysis
statistical plan model performance
Statistical plan – model performance
  • We tested the accuracy of the Kucher score and the new logistic regression model to classify patients by receiver operating characteristic (ROC) curve analysis, plotted as 1-specificity versus sensitivity for VTE diagnosis
    • The c statistic (area under the curve), representing the ability of the model to correctly classify patients, was estimated using the nonparametric method of Hanley and McNeil
  • We validated the model using a risk factor database of patients enrolled at an outpatient

DVT clinic at King’s College Hospital

statistical plan model performance1
Statistical plan – model performance
  • We interpreted the predicted probabilities from the logistic regression model as a risk score
    • each tenth of predicted risk was scored as 1
      • i.e. lower tenth of risk = risk score of 1; upper tenth of risk = risk score of 10
  • We assessed the degree of agreement between the observed rate and the predicted rate of VTE by plotting the risk score vs. observed VTE rate
    • Differences in the rates of VTE vs. increasing risk score were assessed using the χ2 test for trend
results study populations
Results - study populations



Assessment cohort (n=5938)

8 risk factors known

VTE status known

Univariate regression


Development cohort (n=5241)

12 risk factors known

VTE status known

Multiple regression





Validation Cohort (n=915)

12 risk factors known

VTE status known

receiver operating characteristic roc curves for risk score prediction of vte
Receiver operating characteristic (ROC) curves for risk score prediction of VTE

Kucher (––)

c statistic 0.617

95% CI 0.599–0.634

VERITY (- - -)

c statistic 0.720

95% CI 0.705–0.735

VERITY significantly better than Kucher (p<0.001)

proportion of patients with vte vs risk score
Proportion of patients with VTE vs. risk score

Strong positive correlation between an increasing risk score and the percentage of VTE-positive cases in the development cohort (P<0.001 by χ2 test for trend).

VERITY risk score

Kucher risk score

validation cohort roc curves for risk score prediction of vte
Validation cohort: ROC curves for risk score prediction of VTE

Kucher (––)

c statistic 0.587

95% CI 0.542–0.632

VERITY (- - -)

c statistic 0.678

95% CI 0.635–0.721

VERITY c statistic no different from development cohort (p=NS)

  • The c statistic for this VERITY risk model (0.72) indicates a good test for likelihood of VTE diagnosis
  • This VERITY risk model was superior to Kucher for predicting the likelihood of a diagnosis of VTE in a cohort in whom the diagnosis was suspected
  • This risk model was validated in an independent VTE database
  • A prospective study is required to determine clinical value as a risk prediction tool for VTE at the time of hospital admission to assist in assessing prophylaxis needs