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Chem 509 Signal Transduction Winter 2012

Chem 509 Signal Transduction Winter 2012. Lecture 1. 6 general classes of receptors. Ligand, agonist, antagonist. Autocrine, paracrine, endocrine: three mechanisms of signaling cells. Fight or Flight Response.

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Chem 509 Signal Transduction Winter 2012

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  1. Chem 509 • Signal Transduction • Winter 2012 Lecture 1

  2. 6 general classes of receptors

  3. Ligand, agonist, antagonist

  4. Autocrine, paracrine, endocrine: three mechanisms of signaling cells

  5. Fight or Flight Response http://monmouthfamilywellness.com/yahoo_site_admin/assets/images/fight-or-flight.107165735_std.jpg

  6. Cholera http://blackminis.wordpress.com/2008/ 12/12/winter-brings-infection/ Vibrio cholerae http://geo.arc.nasa.gov/sge/health/sensor/diseases/cholera.html

  7. Protein Kinase A AKAP: A kinase anchoring protein

  8. Termination of beta adrenergic signaling pathway: • Epinepherine concentration is lowered. • GAP activity of Gs alpha (GTP converted to GDP) • cAMP phosphodiesterase • Phosphorylation of beta-adrenergic receptor -kinase is beta-adrenergic receptor kinase(BARK) -also known as G protein-coupled receptor kinase 2 • Association of phosphorylated beta-adrenergic receptor with arrestin. This is followed by receptor endocytosis.

  9. End of Lecture 1

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