FutureSearch Clinical Trials, L.P. 5508 Parkcrest Drive, Suite 300, Austin, TX 78731

1. FutureSearch Clinical Trials, L.P. 5508 Parkcrest Drive, Suite 300, Austin, TX 78731 EARLY PHASE CAPABILITIES Presented By Bobbie Theodore, Alliance Director clinicaltrials@btheodore.com www.clinicaltrialcenters.com

2. FutureSearch Clinical Trials, L.P. • Facility • Affiliated with Texas Neuro Rehab Psychiatric Residential Center • 14 rooms (28 beds) • 24-hr Locked Unit, CRU fire alarm system, synchronized timing/clock system throughout • Cardiac Monitoring Capability • 24-hr Medical Staff • Licensed Kitchen with full-time chef for in-house meals • Full Time Staff • Full-time Inpatient staff • PI with 9+ years research experience • 2 MD Sub-Is – 1 Psychiatrist & 1 Neurologist • Full-time MD and PhD-level raters • RNs, and LVNs ACLS/ALS or BLS certified • Site Manager with 8+ years research experience • CCRCs with 5+ years research experience • Recruitment specialists with over 6 years research experience • Provides special pharmacy services including IV dose preparation, randomization, blinding, radio-labeling

3. FutureSearch Clinical Trials, L.P. • CNS Trial Experience Since 1998 • Pediatric to Adult ADHD, Addiction, Alcohol Dependence, Anxiety, Bipolar Depression and Disorder, Depression, Eating Disorders, Mild Cognitive Impairment, Schizophrenia, Schizoaffective • Early Phase Trial Experience • Phase I MDD • Phase I bio-equivalence bipolar, and acute agitation associated with bipolar disorder • Phase IIa Schizophrenia, and Schizoaffective Disorder • First human dose/first in man with new chemical conducted within last 2 years • ADHD

4. FutureSearch Clinical Trials, L.P. • Experience and Capabilities • Psychometric Ratings • Extensive PKs • 3T MRI Scanner capable of FMRI Procedures • EEG/qEEG, Evoked Potentials • Cardiac/Telemetry Monitoring • QtC and TQT • Ambulatory BP Monitoring • Holter Monitoring • OP Exam capabilities within one mile • Infusions • Emergency Capabilities and Training • Staff trained and qualified in use of emergency crash cart, CPR, AED, oxygen tank • Stocked emergency cart checked every shift • Automatic defibrillators on site tested and calibrated annually • 5 miles to nearest trauma or intensive care center – Fully Accredited St. David’s South Austin Medical Center

5. FutureSearch Clinical Trials, L.P. • Clinical/Analytical Specimens and Laboratory • Relationship with CPL local certified lab for local laboratory services • 1-2 day turn-around time for safety lab report results • 24/7 Pick-up • CPL for high priority processing • Electronic transmission capabilities • Refrigerated and ambient centrifuges • Alarmed refrigerators/freezers (-20, -70 and -80 degrees) monitored daily by staff • Back-up Generator • Data Collection • Collection and integration of laboratory data, images and scans • Call center with detailed metrics and recruitment plans tailored to each study • Central or local lab

6. Phase I and IIa Sample Metrics

7. Phase I and IIa Sample Metrics (cont’d)

8. Recruitment • Austin, TX - Over 1 million population • Site Database of 10,000+ subjects across all indications accumulated over 10 years of research • Full-time field-based recruiters with direct access to and contact with patients through board and care homes and community groups for referrals including from The Lakes, a local inpatient psychiatric unit • Community Outreach efforts include attending community events, providing free seminars, lunch and learns, and distributing flyers • Full-time Community Liaison builds and maintains relationships with a network of local physicians (Neurologists, Psychiatrists and Internists) with access to patient databases for additional patient referrals • Internal Call Center with 4 full-time staff members field calls and emails from interested participants and schedule them accordingly with our clinicians to be further evaluated • Full-time Marketing Manager • Ability to pre-qualify patients via IRB-approved pre-screen consent form for queries allowing non-evasive procedures • Relationship with media buyer with history of successful advertising

9. Retention • High Retention / Low Drop Out: • Experienced M.D. always available on site at all patient visits • Highly trained and experienced staff very knowledgeable and comfortable working with these patient populations • Flat screen TVs in some rooms and in all common areas • Wireless Internet and community computers allows patients to keep in touch • Caterer prepares palatable meals and protocol mandated special diets if required • Transportation provided by site when needed for compliance with scheduled visits • Dedicated staff for regular contact with patient and family to promote retention • Lounge, break room, dining room with kitchen

10. Site Advantages • Swift start up – Central IRB • IRB-approved pre-screen consents to pre-qualify subjects • PI provides clinical feedback and protocol consult during development process if needed • Ability to recruit quality patients • Low drop out / high retention • Placebo separation results • Experienced, dedicated staff and PI expertise • Favorable Sponsor and CRO audit results • Responsiveness and ease of single point of contact with Site Relations Team: Bobbie Theodore, Annie Speno and Jeanette Caruso

11. Rating Expertise Includes: Certified, experienced raters, including M.D., Ph.D. and M.A.-level

12. Curriculum Vitae

13. Contact Info • Website: www.clinicaltrialcenters.com • For more information or to arrange a site visit, please contact Alliance Team: Bobbie Theodore – Alliance Director clinicaltrials@btheodore.com email (866) 669-0234 or (916) 939-6696 Annie Speno – Operations Manager annie@btheodore.com email 916-934-0569 phone / 866-745-8708 fax Jeanette Caruso – Site Liaison & Budgets/Contracts Manager jeanette@btheodore.com email 916-933-3023 phone / 916-933-3097 fax