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Evolutionary Insights: Transferrin Proteins in Various Species

Explore the evolutionary relationships and conserved regions in transferrin proteins across diverse organisms. Molecular phylogenies shed light on the historical changes in these vital molecules. Discover the role of transferrin through comparative analysis.

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Evolutionary Insights: Transferrin Proteins in Various Species

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  1. “Transferrins-R-US” “An Evolutionary look at the changes in the structure of this protein” Geoffrey

  2. What’s our Question? • What is the evolutionary relationship among various species using the transferrin protein as a model? • How much of the transferrin molecule is conserved in these organisms?

  3. What’s the role of transferrin?

  4. Molecular Phylogenies • Molecular sequencing illuminates the evolutionary history of the molecules themselves and, consequently that of their host organisms.

  5. Organisms Used • Protostome - Arthropoda – Insecta • Apis mellifera (Honey Bee) • Chilo suppressalis (Striped Rice Borer) • Bombyx mori (Silkmoth) • Manduca sexta (Carolina Sphinx) • Galleria mellonia (Greater Wax Moth) • Sarcophaga spp.(Flesh Fly) • Drosophila silvestris (Picture Winged Fly) • Periplaneta americana (Cockroach) • Protoctista • Trypanosoma brucei (African Sleeping Sickness) • Deuterostome -Echinodermata – Echinoidea (Sea Urchins) • Strongylocentrotus purpuratus • Paracentrotus lividus • Tripneustes gratilla • Lytechinus variegatus • Chordata -Mammalia • Homo sapiens bioinformaticus (John Jungck) • Mus musculus (Mouse) • Bufo spp. (Toad) • Oncorhynchus mykiss (Rainbow Trout) • Chordata-Urochordata • Halocynthia roretzi (Sea squirt)

  6. Lord of the Flies

  7. It’s a Bug’s Life!

  8. The “Stars” of the Show

  9. Mastodon-free Zone!

  10. “To chordate or not to chordate?, That is the Question!”

  11. Outsiders? We don’t want no stinkin’ outsiders!

  12. What does this mean? • Cladograms • Deuterostomes separate from protostomes • Similar species cluster together • Does not reflect a pattern in single lobe vs. double lobe molecules

  13. More of what does this mean… • Molecular structure • There are few conserved regions • Not very conserved around functional areas • Only 3 of 8 disulfide bridges and only 1 of 2 hinge strands are conserved

  14. That’s all Folks!

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