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The marker of risk factor(s) for Vibrio vulnificus infection

The marker of risk factor(s) for Vibrio vulnificus infection. Speaker: 彭佳琇. (1980-2004). Am Fam Physician Physician 2007;76:539-44, 546.

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The marker of risk factor(s) for Vibrio vulnificus infection

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  1. The marker of risk factor(s) for Vibrio vulnificus infection Speaker: 彭佳琇

  2. (1980-2004)

  3. Am Fam Physician Physician 2007;76:539-44, 546.

  4. Iron overload, documented by high transferrin saturation, is common in patients with liver disease and other immunocompromising conditions who develop V. vulnificus infection. Patients with chronic liver disease have a much higher risk of septicemia and death; approximately 80 % of deaths occur in patients with liver disease. J Infect Dis 1998;178:752-9. In human and animal studies, high levels of free iron have markedly increased the growth and lethality of V. vulnificus. Microbiol Immunol 2000;44:871-8.

  5. Mechanism of high susceptibility of iron-overloaded mouse to Vibrio vulnificus infection. Microbiol Immunol. 2000;44(11):871-8. Hor LI, Chang YK, Chang CC, Lei HY, Ou JT. • Vibrio vulnificus produces fulminant septicemia in humans with underlying conditions, particularly those with diseases that elevate the iron level. • The effect of a high iron level on the virulence of V. vulnificus was therefore investigated in mice treated with iron dextran.

  6. Iron-overloaded mice + Vibrio vulnificus infection Mortality • Iron increased the growth rate of the bacteria • (quickly reaching a lethal concentration in the iron-overloaded mouse.) • Iron overload stimulated the production of TNF-a(a major factor of septic shock), in mice upon infection with the bacteria, probably caused by the endotoxin • Neutrophils migration is effected by TNF-a, appeared to be less active.

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