Hemostatic System - general information. Normal hemostatic system vessel wall circulating blood platelets blood coagulation and fibrynolysis Platelets Anucleate disc-shape cell fragments arise from megakariocytes in bone marrow 1/3 of platelets are sequestrated in the spleen
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Decreased marrow production of megakariocytes
Splenic sequestration of circulating platelets
Increased destruction of circulating platelets