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Low Cost Blood Analyzer for Malaria Detection

Low Cost Blood Analyzer for Malaria Detection. Project Advisors: Prof. William Tang, Gelareh Eslamian Project Team: Nadia Ahmed, Kevin Cho, Johnway Yih, Anna Grace Additional Help: Timothy Quang , Robert Diehl, Ling Kong, Transon Nguyen, Kun Qian. Background.

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Low Cost Blood Analyzer for Malaria Detection

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  1. Low Cost Blood Analyzerfor Malaria Detection Project Advisors: Prof. William Tang, GelarehEslamian Project Team: Nadia Ahmed, Kevin Cho, Johnway Yih, Anna Grace Additional Help: Timothy Quang, Robert Diehl, Ling Kong, Transon Nguyen, Kun Qian

  2. Background Malaria affects 500 million people a year The most common and lethal of four different strains of malaria is Plasmodium Falciparum www.sciencemag.org on June 1, 2010

  3. Purpose • Avoid misdiagnosis (which leads to drug resistance) • Provide cheap and reliable diagnosis • Keep the device portable • Create an alternative to slow and expensive microscopy blood analysis Properly diagnose Malaria in a cheap and effective manner

  4. Project Theory • Malaria targets red blood cells (RBC) • Infected RBCs become more rigid and form a rough exterior • Infected RBCs travel slower than non infected RBCs • Infection can be quantified and measured based on flow speed of RBCs www.pnas.orgcgidoi10.1073pnas.2433968100

  5. Project Design • Create an optical sensor with a laser diode and photodiode • Flowing RBCs will interrupt the laser beam • Disruption of the laser beam will be recorded by voltage output of photodiode • Use National Instruments DAQ to record information on a PC

  6. Project Design

  7. Project Design

  8. Data Photodiode readout of wire (~500 µm) test

  9. Data Photodiode readout of hair (~100 µm) test

  10. Microfluidic Channels • Shrinky dink mold method • Print channel layout on polystyrene • Oven at 160-170 degrees Celsius • Problems keeping them flat • Pour PDMS on top of shrinky dinks • Adhere PDMS to glass slides to create permanent channels

  11. PDMS Channel

  12. Continued Work • Focus the laser beam to the smallest spot size possible • Detect microbeads flowing through a microchannel (~10 µm) • Detect RBCs (~4-8 µm) in mouse blood

  13. Ultimate Goal • Reverse engineer common CD ROM drives • Use the internal optical system for our device • Optical sensors will already be sensitive enough • Cheap alternative to constructing our own materials

  14. Thank You Project Advisors: Prof. William Tang, Gelareh Eslamian Project Team: Nadia Ahmed, Kevin Cho, Johnway Yih, Anna Grace Additional Help: Timothy Quang, Robert Diehl, Ling Kong, Transon Nguyen, Kun Qian

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