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UTMB CTSA recompetition strategies. No FOA-what we know…. IOM report stresses… Build on unique strengths Innovate and evaluate what we do Education of a broadworkforce will continue to be a focus We must show participation and value to the national consortium NCATS Directorship says…

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no foa what we know
No FOA-what we know…
  • IOM report stresses…
  • Build on unique strengths
  • Innovate and evaluate what we do
  • Education of a broadworkforce will continue to be a focus
  • We must show participation and value to the national consortium
  • NCATS Directorship says…
  • TR is a team activity
  • Partner/leverage
  • Show value to communities, stakeholders, NIH ICs
  • UTMB-centric
    • Build on Translational Teams to leverage our unique institutional strengths and innovation in clinical research
    • Grow clinical trials
    • Strengthen PCOR
  • TRCC-centric
    • Disseminate CI&EP throughout the TRCC
    • TRCC KL2 Network
    • Responsible Conduct for Research?
    • Community engagement
    • Clinical trial network
  • National consortium-centric
    • SGC3 Team Science Initiative
    • National Mentoring Research Network
innovation in educational activities
Innovation in educational activities
  • What we have implemented:
  • Clinical science PhD in medical bioinformatics-
  • Human Pathophysiology and Translational Medicine
  • Certificate Programs
  • Entrepreneurship, bioventure- (now being launched at the TMC)
  • Systems biology
  • PCOR
  • Modules in translational team management
  • Collaborative Innovation and Entrepreneurship Program (CI&EP)

Alignment of Training and Education Activities

with MTTs

Collaborating Investigators

Team Workshops

Team Leadership



Established Investigator

Clinical Science Program


















Health Care











Tools and Techniques

Strategic core




BT Ameredes, in preparation


The Texas Regional CTSA (TRCC) Collaborative Innovation and Entrepreneurial Program (CI&EP)

  • Year 1: Implementation Findings and Recommendations

The broad aim of the CI&EP initiative is to accelerate the translation of innovative technologies and processes into successful commercial ventures.

The initiative seeks to spur innovation through educational training partnerships with UT Austin-McCombs School of Business (UT), NASA Johnson Space Center (NASA JSC), and University of Houston, Clear Lake (UHCL).

Christina M. Cestone, PhD

ci ep implementation schedule 2012 2013
CI&EP Implementation Schedule (2012-2013)

*Maximum enrollment 25.

Christina M. Cestone, PhD

course enrollment metrics
Course Enrollment Metrics

Christina M. Cestone, PhD


N=33 (~30% of enrolled)

71% held terminal degrees,

    • 41% PhDs (Research Scientists, Postdocs)
    • 17.6% MDs (Faculty and Research)
    • 11.8% MD/PhDs
  • Remaining trainees pursuing advanced degrees or staff.
  • 65% between 25 and 35 Y/O

Christina M. Cestone, PhD

key findings
Key Findings
  • Participants reported the Management of Technology course influenced, to a large or very large extent, their perceived ability to commercialize scientific discoveries.
  • Participants reported learning the business terminology necessary to lead cross-disciplinary scientific collaborations.
  • Participants reported immediate utility of Business Innovation course concepts.

Christina M. Cestone, PhD

leveraging the trcc
Leveraging the TRCC

This meeting’s outcomes in clinical research networks- Conduct multi-site clinical trial throughout the TRCC- would be extremely powerful.

Several trials under development:

    • N. Abate CER on NASH associated with type 2 DM in hispanics
    • D. Herndon, DOD-funded multi-site trial in burns treatment

Infrastructure provided by CTSA

  • Harmonization of processes (Master Trial Agreements, etc.)
  • Data management/Data coordinating center(s)
  • Inventory of clinical trialists
  • Link Cores- MOU-
leveraging the trcc1
Leveraging the TRCC
  • Education
  • Disseminate CI&EP throughout the TRCC- bioventures now hosted at the TMC
  • TRCC KL2 Network
  • Responsible Conduct for Research?
  • Mentoring- mentoring network throughout the TRCC- perhaps contribute to CTSA-National Research Mentoring Network (NRMN, PIs-C. Bylington, Univ. Utah, K. Freund, Tufts Univ.)
  • We need a mechanism for keeping track of working groups- Executive committee?
national agenda sgc3 team science affinity network
National Agenda- SGC3 Team Science affinity network-

Goals are:

  • To produce an integrated development/education/evaluation group;
  • Share and disseminate evidence-based practices;
  • Conduct and evaluate evidence-based research interventions across CTSA sites. For example:
    • collaboration readiness/needs assessment,
    • collaboration skills training,
    • meeting management training
    • evaluation
mtts to promote translational research
MTTs to promote translational research
  • How CTSAs can support teams:
  • Calhoun, WJ, Wooten, K, Bhavnani, S, Anderson, KE, Freeman, J, and Brasier,AR. The CTSA as an Exemplar Framework for Developing Multidisciplinary Translational Teams. ClinTransl Sci. 6(1): 60-71, 2013.
  • Interventions to improve team leadership and functions
  • Bhavnani, S.K., Farroni, J. S., Crowder, J., McKinney, B., Pillai, R., Calhoun W. J., Rose, R.M. Carter, M.A. The Role of Method Intuition in Translational Ethics. Proceedings of AMIA Summit on Translational Bioinformatics (2012).
  • We’ve refined our MTT review process for assessing collaboration readiness, supported 16 teams with CTSA-ascribable grant outcomes and publications
  • We’ve demonstrated the transformative impact of the CTSA on culture
  • Kotarba, J, Symbolic Interaction and Applied Social Research: A Focus on Translational Science Research, Symbolic Interaction , Volume 37, Number 2 (2014)
evaluating outcomes of mtts
Evaluating outcomes of MTTs

Mixed methods assessment of team project outcomes and longitudinal assessment of development

  • Wooten, KC, Rose, RM, Ostir, GV, Calhoun, WJ, Ameredes, B.T. and Brasier, AR. Assessing and Evaluating Multidisciplinary Translational Teams: A Case Illustration of a Mixed Methods Approach and an Integrative Model. Evaluation in the Health Sciences, 2014.
current status
Current status
  • Assembled and met with steering committee (H. Falk-Krzesinski, Elsevier;
  • K. Hall, NCI; B. Spring, NWU; D Ilgen, Univ. MI; E. Salas, U. of Fla: B. Trochim, Columbia;
  • M. Bennett, NIH; J. Keyton, NCU; D. Rubio, UPitt).
    • The committee endorsed our research-oriented plan and will work with
    • us to coordinate with ongoing IOM/NSF initiatives.
  • 2 organizational teleconferences in July and August and one organizational
  • meeting
  • Currently, 27 participants from 12 distinct CTSA sites:
  • 12 in education
  • 16 in team development
  • 12 in evaluation
  • Immediate goals:
  • Develop uniform ontologies
  • Identify major needs in team science in participating CTSA sites
  • Prioritize, deploy and evaluate team science educational activities
ctsa national research mentoring network
CTSA National Research Mentoring Network

Goal is to increase diversity of the biomedical workforce (URM, LES).

One network will be funded in 2014 through the NIH common fund. It is expected that

the network will be closely integrated with the CTSA, CC-CHOC, ACTS,

and BUILD networks and others.

This summer, P20 planning grants were awarded to 6 sites,

one (Blyington and Freud) supported by41 CTSA PIs. A planning meeting was held in

Philadelphia last week.

Although the FOA not released, the goal is to develop, disseminate and evaluate

evidence-based strategies for promoting URM involvement in the biomedical workforce.

The TRCC could be a meaningful contributor to the NRMN