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This image challenge highlights the abnormal serum levels expected in patients with sarcoidosis, specifically focusing on angiotensin-converting enzyme (ACE) levels. Lupus pernio, often manifesting on the nasal bridge and cheeks, is a common feature of sarcoidosis. Notably, ACE levels are elevated in many untreated sarcoidosis patients, making it a crucial laboratory test in the diagnosis and management of the disease. This information is vital for clinicians approach to interpreting lab results in suspected cases of sarcoidosis.
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Image Challenge Q: Serum levels of which one of the following laboratory tests would be expected to be most abnormal in this patient? 1. 17-hydroxyprogesterone 2. Angiotensin-converting enzyme 3. Anti-tissue transglutaminase antibody 4. Prolactin 5. Vitamin B6
Image Challenge Q: Serum levels of which one of the following laboratory tests would be expected to be most abnormal in this patient? Answer: 2. Angiotensin-converting enzyme Lupus pernio is a manifestation of sarcoidosis that involves the nasal bridge and cheeks. Serum levels of the angiotensin-converting enzyme are elevated in the majority of patients with untreated sarcoidosis.
