Medical Aspects of Death

1. Medical Aspects of Death

2. Death • Cessation of life • Is it event or process • When does death actually occur? • “Cellular Death” • “Somatic Death”

3. Cellular Death • Cessation of Respiration • Followed by autolysis • Skin, bone: remain active for hours • WBC: can move 12 hours after cardiac arrest • Neurons: 3-7 minutes

4. Somatic Death • Individual will never communicate with the environment • Irreversible • “True” Death

5. Resuscitation • Results of resuscitation • Recovery of consciousness and breathing • Not conscious , but can breathe • Not conscious, and Cannot breathe without mechanical ventilator

6. Brain Death

7. Code of Practice concerning Brain Death in UK (1970) • Deep coma (excluding treatable causes) • Need of mechanical ventilator • Firm diagnosis of pathology and brain damage • Tests for brain stem death must be positive

8. Code of Practice concerning Brain Death in UK (1970) • Absent cerebral function • Absent brain stem function • Apnea

9. Code of Practice concerning Brain Death in UK (1970) • Cerebral Cortex: • Cognition • Voluntary movement • Sensation

10. Code of Practice concerning Brain Death in UK (1970) • Mid brain • Cranial nerve III • Pupillary function • Eye movement • Pons • Cranial nerve IV, V, VI • Conjugate eye movement • Corneal reflex • Medulla • Cranial nerve IX, X • Gag reflex • Cough reflex • Respiration

11. Clinical Tests • Brain stem reflexes are absent with fixed dilated unreactive pupils • No motor response to painful stimuli to any cranial nerves • No gag reflex • No respiratory movement • Test performed in >35 degrees temperature

13. Causes of Brain Death • Cerebral anoxia • Cerebral hemorrhage • Subarachnoid hemorrhage • Trauma • Meningitis

18. Persistent Vegetative State

19. Persistent Vegetative State • Long term survival of unconscious but spontaneously respiring patient • There is some brain stem activity • No higher cerebral function • Medical treatment can be withdrawn • ?? Withdraw nutrition and hydration

20. Death Certificate

21. Example of Death Certificate

22. Questions need answers • Who is the deceased? • When & Where did death occur? • How did he/she died? • If we can answer the questions we can sign the Death certificate!

23. Death Certificate • Cause of Death • Manner of Death

24. Death Certificate • Cause of Death • Part I: Conditions that led directly to death • A • B due to: • Cdue to • Part II: Other conditions (may contribute to death)

25. Death Certificate • Is this Correct?! • Death certificate written: • Cause of death: • Cardio-respiratory arrest • Cause of death: • Old age • Cause of death: • Heart failure

26. Death Certificate • Manner of Death: • Natural • Homicide • Suicide • Accidental • undetermined

27. Medico legal investigation • If death is natural and the doctor can sign death certificate, no investigation needed. • If death certificate cannot be singed, we usually need medico legal investigation

28. Why cannot sign death certificate • Unnatural death • Homicide • Suicide • Suspicious • Traumatic • Violence • Neglect • Poisoning • Unexpected unexplained • accidental

29. Exercise: • 56 year old man is diagnosed to have pancreatic cancer. He is admitted to hospital for possible surgical resection. While in the hospital the patient develops DVT in the deep vein of legs. The next day, the condition is complicated by pulmonary thromboembolism. He dies few hours later. • How do you write the Cause of Death?

30. Exercise: • Following a car accident a young male patient, 24 years old develops head injury. He is found to have subarachnoid hemorrhage. He develops pneumonia and dies few days late. • He is also HIV positive. • How do you write the cause of Death?