32. البقرة : من الآي ة. بسم الله الرحمن الرحيم. قالوا سبحانك لا علم لنا إلا ما علمتنا إنك أنت العليم الحكيم. صدق الله العظيم. Probiotics and the Skin. Nagwa M. Elwan , M.D Prof. of Dermatology, Tanta – Egypt Azza El.Toukhy , Shereen Gheida & Wallaa Abdel- Azeem , Tanta.
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البقرة: من الآية
بسم الله الرحمن الرحيم
قالوا سبحانك لا علم لنا إلا ما علمتنا
إنك أنت العليم الحكيم
صدق الله العظيم
Nagwa M. Elwan, M.D
Prof. of Dermatology, Tanta – Egypt
AzzaEl.Toukhy, ShereenGheida & Wallaa Abdel-Azeem, Tanta
The concept of functional foods was introduced long time ago with Hippocrateand his motto: (let food be your medicine).
Among a number of functional foods, fermented foods and probiotics take the center stage due to their long traditional safe use, established and postulated beneficial effects.
The term probiotics meaning (for life), is derived from Greek language.
Growing scientific evidence supporting the concept that maintenance of healthy gut microbiotamay provide protection against:
* GIT disorders
* IBD (inflam.bowel dis.)
Dominant microbial genera in the adult human gastrointestinal tract.
* CFU: colony forming unit.
The theoretical basis for the selection of probiotic micro-organisms :
The main probiotic bactaria used in dairy products are:
bifidobacteria can affect :
* Antigen presenting cells ( DCs
& monocytes )
* Regulatory T cells
* T & B cells
Schematic representation of the multiple consequences of the cross-talk between the probiotic bacteria and the intestinal mucosa
Probiotics are under study for a variety of pathophysiological states including:
The main risks associated with probiotic use are:
All cases of probiotics bacteremia or fungemia have occurred in immune compromised patients, chronic disease, or debilitation, but no reports of sepsis related to probiotics use in healthy persons.
B- Immune deviation or excessive immune stimulation:
Probiotics have been shown to suppress Th2 cytokine and increase production of Th1 cytokine. These effects may be detrimental to pregnancy viability.
C- Deleterious metabolic activities:
The intestinal microbiota play an important role in many metabolic activities, including complex carbohydrate digestion, lipid metabolism, and glucose homeostasis. Therefore there is a theoretical risk of adverse metabolic effects from manipulation of the microbiota with the use of probiotics, even if such manipulation is only temporary.
Many probiotic strains are naturally resistant to vancomycin, which raises concerns about possible transfer of such resistance to more pathogenic organism.
Risks associated with probiotics as treatment
Defined as ‘‘nondigestible - food ingredient (s) that beneficially affects host health by selectively stimulating the growth and/or activity of one or a limited number of bacteria in the colon’’.
Is a product containing prebiotics and probiotics and in which the prebiotics compound selectively favors the probiotics.
The concept of modulation of micro-flora originally developed for gut