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Hodgkin’s Disease

Hodgkin’s Disease. By: Bailey Rogers. http://www.gutenberg.org/files/17921/17921-h/images/fig080.jpg. Definition and History. The Lymphatic System.

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Hodgkin’s Disease

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  1. Hodgkin’s Disease By: Bailey Rogers http://www.gutenberg.org/files/17921/17921-h/images/fig080.jpg

  2. Definition and History The Lymphatic System • Hodgkin’s Disease is a neoplastic disorder originating in the lymphatic system/lymph nodes. It is usually defined by the presence of Reed-Sternberg cells. • Thomas Hodgkin discovered this disease in 1832 and has since been known as Hodgkin’s Disease. http://miyessence.files.wordpress.com/2006/12/lymphatic.gif

  3. Causes • Unknown • However believed to be a virus http://www.library.uni.edu/instruction/images/questionmark.jpg

  4. Effects / Symptoms Symptoms include • Painless swelling of lymph nodes • Fever/chills • Night sweats • Weight loss • Itching • Occurs more often in adolescents and people over the age of 55 http://www.healthoma.com/images/posts/hodgkins-disease-pictures.jpg

  5. Stage 1 • Only a single lymph node region is involved Stage 2 • Lesions are on one side of the diaphragm Stage 3 • Both sides are involved Stage 4 • Widespread involvement of the lymph node sites The Stages of Hodgkin's Disease

  6. Diagnosis • Presence of Reed-Sternberg cells in a biopsy of the lymph node tissue • X-rays of parts of the body that may be affected • Body Scan http://www.postgradmed.com/issues/2002/03_02/hodgkinsa.jpg

  7. Reed-Sternberg Cells • These cells are giant having two nuclei that are situated in a mirror-image fashion. http://hematopathology.stanford.edu/images/HP-Home-Image.jpg http://pathology.catholic.ac.kr/pathology/specimen/lymph/he30.jpg

  8. Treatment • Treatment varies, can include radiation therapy or chemotherapy http://medicineworld.org/images/blogs/10-2007/guided-radiation-therapy.jpg

  9. Future Outlook/ Research • Henry Kaplan and Saul Rosenberg first used radiation to treat Hodgkin’s disease in the 1960s • Lymphoma and Hodgkin’s Disease Research Program continues this legacy through investigations into immune system cancer and its molecular and genetic origins • Since then they have Introduced a number of important advances, including the first FDA-approved monoclonal antibody for cancer treatment (Rituxan)

  10. Statistics / Other Information • Survival rate for patients with Hodgkin's disease has increased from 40% in whites from 1960-1963 to more than 86% for all races in 1996-2003 • Estimated 71,380 people in the US were diagnosed with lymphoma in 2007 ( 8,190 cases were Hodgkin’s and the rest Lymphoma) • Among the new cases of Hodgkin’s Disease 4,470 were males and 3,720 were female • 3rd most common cause of cancer in children • In 2005 10%-15% of cases were found in cilderin under the age of 16

  11. The End

  12. Reference page Yale Medical Group. (2005) Hodgkin’s Disease. Retrieved April 8, 2008 on the world wide web : http://ymghealthinfo.org/content.asp?page=P00094 Bunch, Bryan (2003) Diseases : Fever to Hypothermia. Grolier Educational Corporation (pages 99 – 100) National Cancer Institute (2008) Hodgkin’s Disease. Retrieved April 6, 2008 on the world wide web http://www.nlm.nih.gov/medlineplus/hodgkinsdisease.html The Leukemia and Lymphoma Society (2008) Hodgkin Lymphoma Facts and Statistics. Retrieved April 6 2008 on the world wide web http://www.leukemia-lymphoma.org/all_page?item_id=8312 Nassar .H Victor “Hodgkin’s Disease” Magills Medical Guide (2002) . Vol 2 p 1121-1125 Stanford Cancer Center (2008) Lymphoma and Hodgkin's Disease Research Program. Retrieved May 5 2008 on the world wide web <http://cancer.stanford.edu/research/lymphoma/>

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