Increased Prevalence of Preterm Birth in Asymptomatic Neonates with  Congenital Cytomegalovirus (cCM...
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Increased Prevalence of Preterm Birth in Asymptomatic Neonates with Congenital Cytomegalovirus (cCMV).

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Increased Prevalence of Preterm Birth in Asymptomatic Neonates with Congenital Cytomegalovirus (cCMV)

Vedanta S. Dariya, M.B;B.S.1,2, A. Chantal Caviness, M.D., M.P.H., Ph.D.1, Marily Flores, M.S.1, Holly Corwin, M.P.H.1 and Gail J. Harrison, M.D.1 for the Houston Congenital CMV Longitudinal Study

1Pediatrics, Baylor College of Medicine, Texas Children's Hospital, Houston, Texas (77030),U.S.

2 Neonatal-Perinatal Medicine Post-doctoral Fellow




  • cCMV affects ~1% of all newborns born annually in the U.S.

  • ~ 10% born with symptoms typically associated with cCMV

    • Most develop sequelae: sensori-neural hearing loss , visual impairment and neuro-developmental disabilities

  • ~ 90% appear asymptomatic at birth (AcCMV)

    • May develop long-term sequelae

  • Subtle differences may exist when comparing AcCMV infants and uninfected newborns (NoCMV)

  • Hypotheses

  • Gestational age(GA) of AcCMV will differ from NoCMV

  • Birth characteristics of weight, length and head circumference of AcCMV differ from NoCMV


  • No differences in maternal age/delivery type between the two groups

  • Difference in race/ethnicity likely due to large number of missing data

  • Significant difference in number of multiple gestation births

*Demographic data

  • Mean gestational age of AcCMV < NoCMV

  • Frequency of preterm birth in AcCMV > NoCMV

  • Frequency of multiple birth in AcCMV > NoCMV

Study Design

  • In singleton births, AcCMV more likely than NcCMV to be preterm

*Gestational age and Preterm birth

*Study Design: Prospective, longitudinal follow-up study

  • All infants: AcCMV significantly smaller than NoCMV

  • Term infants: AcCMV appear smaller than NoCMV (findings not statistically significant)

*Birth characteristics


#Clinical findings s/o cCMV: SGA, Generalized petechiae, Hepatomegaly, Splenomegaly, Microcephaly, Jaundice at birth

  • Asymptomatic congenital CMV subjects were more likely to be born preterm than uninfected controls

  • Asymptomatic congenital CMV subjects were smaller than uninfected controls, however this finding was not significant when only term infants in both groups were compared


^Testing for CMV

Urine samples of patients born on the same day tested in batches of 3

Ratio of CMV (+) : Controls 1:2




  • *Classification of Study Subjects

  • # Clinical findings of cCMV

  • ^ Method of recruiting Controls

Williamson WD, Percy AK, Yow MD, et al. Asymptomatic congenital cytomegalovirus infection: Audiologic, neuroradiologic and neuro-developmental abnormalities during the first year. Am J. Dis Child.1990

2012 Texas Pediatric Society Electronic Poster Contest