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The development of nervous system

The development of nervous system. 陳建榮. http://web.nchu.edu.tw/pweb/users/chenjr/. Nervous system: Central nervous system (CNS): brain, spinal cord Peripheral nervous system (PNS): cranial nerves, spinal nerves Autonomic nervous system (ANS). Origin of nervous system.

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The development of nervous system

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  1. The development of nervous system 陳建榮 http://web.nchu.edu.tw/pweb/users/chenjr/

  2. Nervous system: • Central nervous system (CNS): • brain, • spinal cord • Peripheral nervous system (PNS): • cranial nerves, • spinal nerves • Autonomic nervous system (ANS)

  3. Origin of nervous system • Neutralization: • Notochord  • Neural plate • Neural groove  • Neural tube, neural crest  • Rostral neuropore, caudal neuropore

  4. Nonfusion of neural tube

  5. Neual tube: • Neural canal  central canal • Neuroepithelial cell (pseudostratified columnar epi) • Ventricular zone • Intermediate zone • Marginal zone • Alar plate  dorsal horn • Basal plate  ventral horn • Roof plate • Floor plate • Mesenchyme  spinal meninges • Dura matter • Arachnoid • Pia matter

  6. Development of spinal cord

  7. Development of Pseudounipolar neuron

  8. Myelination of nerve fibers

  9. Positional changes of spinal cord 8 weeks 24 weeks child adult

  10. Neural crest

  11. Congenital anomalies of spinal cord Neural tube defects (NTD)

  12. Spinal bifida oculta隱性脊柱雙裂 Spinal bifida cystica脊柱雙裂囊腫 Spinal bifida cystica脊柱雙裂囊腫 Myeloschisis脊髓裂

  13. Neural tube defects (NTD)

  14. Myeloschisis 脊髓裂

  15. Development of brain • 3 primary vesicles: • Forebrain (prosencephalon) • Telencephalon - cerebral hemispheres • Diencephalon - thamaus • Midbrain (mesencephalon) • Mesencephalon - midbrain • Metencephalon - pons, cerebellum • Myelencephalon - medulla • Hindbrain (rhombencephalon)

  16. Brain flexures腦彎 • Midbrain flexure • Cervical flexure • Pontine flexure

  17. Myelencephalon(medulla) Caudal portion Rostral portion

  18. Alar plate • Special somatic afferent (SSA) • CN VIII (hear, vestibular) • General somatic afferent (GSA) • CN V • Special visceral afferent (SVA) • CN VII, IX, X (taste) • General visceral afferent (GVA) • CN X • Basal plate: • General visceral efferent (GVE) • CN IX, X • Special visceral efferent (SVE) • CN V, VII, IX, X • General somatic efferent (GSE) • CN III, IV, VI, XII

  19. Metencephalon

  20. Midbrain

  21. Diencephalon

  22. Pituitary gland: • Adenohypophysis (oral ectoderm) • Hypophysial pouch • Pars tuberalis • Pars distalis • Pars intermedia • Neurohypophysis (neural ectoderm) • Neurohypophysial bud • Pars nervosa • Infundibular stem • Median eminence

  23. Pituitary gland

  24. Ventricles of CNS

  25. Telencephalon

  26. 13 weeks 21 weeks 32 weeks

  27. 38 weeks 25 weeks

  28. Early stage of nervous system • Proliferation • Migration • Differentiation • Organization

  29. Corpus callosum胼胝體

  30. Choroid plexus Cerebrospinal fluid (CSF)

  31. Hydrocephalus 水腦 - excessive formation of CSF - blockage of the circulation of CSF - diminished absorption of CSF

  32. Cranium bifidum顱骨雙裂

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