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Methods for and Applications of Quantitative SPECT

Methods for and Applications of Quantitative SPECT. Medical Imaging Physics Eric Frey, Ph.D. Benjamin Tsui , Ph.D. Yong Du, Ph.D. Xin He, Ph.D. Na Song Xing Rong Michael Ghaly Lishui Cheng Environmental Health Science Jonathan Links, Ph.D. Nuclear Medicine Richard L. Wahl, M.D.

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Methods for and Applications of Quantitative SPECT

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  1. Methods for and Applications of Quantitative SPECT Medical Imaging Physics Eric Frey, Ph.D. Benjamin Tsui, Ph.D. Yong Du, Ph.D. Xin He, Ph.D. Na Song Xing Rong Michael Ghaly Lishui Cheng Environmental Health Science Jonathan Links, Ph.D. Nuclear Medicine Richard L. Wahl, M.D. Heather Jacene, M.D. Frank Bengel, M.D. Cardiology Lew Becker, M.D. Participants

  2. Methods for Quantitative SPECT Imaging Physics Applied Math Estimation Theory Well characterized Accuracy: <5% for organs <10% at system resolution Precision: on order of accuracy Quantitative SPECT • Single Radionuclide: • Tc-99m, Tl-201, In-111, I-131, I-123, … • Simultaneous Dual Radionuclide: • Tc-99m/Tl-201 • Tc-99m/In-111 • Tc-99m/I-123 • In-111/I-131 • Compensation for: • Attenuation • Scatter • Spatially varying resolution • Partial volume effects I-123 Brain Phantom

  3. Clinical Applications of Quantitative SPECT • Targeted radiotherapy dosimetry • Quantitative tumor response (e.g., In-111 Octreoscan, I-123 MIBG) • Simultaneous rest/stress myocardial perfusion imaging • Simultaneous myocardial perfusion/innervation imaging

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