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Michael S. Saag, MD

Initiation of Antiretroviral Therapy: Is Once Enough?. Michael S. Saag, MD. MS Saag, MD. Presented at IAS –USA /RWCA Clinical Conference, August 2004. The International AIDS Society–USA. When to Start: Recommendations for Initiating Therapy. Yeni et al, for IAS – USA. JAMA , 2004.

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Michael S. Saag, MD

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  1. Initiation of Antiretroviral Therapy: Is Once Enough? Michael S. Saag, MD MS Saag, MD.Presented at IAS–USA/RWCA Clinical Conference, August 2004. The International AIDS Society–USA

  2. When to Start: Recommendations for Initiating Therapy Yeni et al, for IAS–USA. JAMA, 2004.

  3. Changing Treatment Guidelines: DHHS: Asymptomatic patients <www.aidsinfo.nih.gov>

  4. AIDS free survival by log HIV-1 RNA at baseline 1.00 <3 3-3.99 0.95 4-4.99 0.90 Probability of AIDS free survival >5 0.85 0.80 0.75 0 1 2 3 Years from starting HAART

  5. Initial Regimens • Generally Recommended • NNRTI + 2 NRTIs • Boosted PI + 2 NRTIs • Generally NOT Recommended • 4-drug regimens • 3-NRTI regimens, except when NNRTI and PI use is precluded • 2-drug regimens or monotherapy (eg, 1 PI)

  6. FTC-301 Efficacy Endpoints at Week 48 Saag et al, JAMA, 2004.

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