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Infection of parasite nematodes confounds vaccination efficacy (Urban et al . 2007). Journal Club of Veterinary Medicine, 18 October 2007. Ingeniøren , 13 October 2007. If you want to be innovative? The get rid of the laid back attitude!

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infection of parasite nematodes confounds vaccination efficacy urban et al 2007

Infection of parasite nematodes confounds vaccination efficacy (Urban et al. 2007)

Journal Club of Veterinary Medicine, 18 October 2007

slide2

Ingeniøren, 13 October 2007

If you want to be innovative? The get rid of the laid back attitude!

It has to hurt a little to participate in an innovation project. If it is too fun and cozy, it does not move, concludes a ph.d.-dissertation.

slide6

Cytokines can prime of T helper cells development

Th0

INF

IL12

TNF

IL4

IL13

IL10

Th1 Th2

Intracellular

Extracellular

slide7

“Infection of parasite nematodes confounds vaccination efficacy”

Veterinary Parasitology. 2007 August 19; 148(1): 14-20

(Urban et al. 2007)

General vaccination strategy

+

Vaccination

Challenge (2nd vaccination)

Antibodies

(IgG1, IgG2)

Cytokines

slide8

“Infection of parasite nematodes confounds vaccination efficacy”

Veterinary Parasitology. 2007 August 19; 148(1): 14-20

(Urban et al. 2007)

Mouse model

+

+

Nematode

Vaccination

Challenge (2nd vaccination)

Heligomosomoides polygyrus

Plasmodium yoelii (malaria antigen, mice)

  • IL3
  • IL4
  • IL5
  • IL9
  • IL13
  • IgG1 & IgE

INF

IL4

IL13

IL10

TGF

slide9

“Infection of parasite nematodes confounds vaccination efficacy”

Veterinary Parasitology. 2007 August 19; 148(1): 14-20

(Urban et al. 2007)

Pig model

+

+

Nematode

Vaccination

Challenge (2nd vaccination)

Ascaris suum

Mycoplasma hyopneumonia (commercial killed vaccine)

  • 33% specific antibody response to M. Hyopnemonia.
  • Serum conversion did not exceed 78 %.
  • More lung pathology
  • Weak Th1 (lungs)
  • Th2 (intestine)
slide10

Parasitic infections as medicine

An inflammatory bowel disease

Chron’s Disease (regional interitis)

Autoimmune disease

Th1-dominated

Th2