HEMATOLOGY JOURNAL CLUB. Mon 17 May 2010 Ahmed S.Barefah King Abdulaziz University Hematology department . Research article. “ Statins protect against fulminant pneumococcal infection and cytolysin toxicity in a mouse model of sickle cell disease.”. Authors.
Mon 17 May 2010
King Abdulaziz University
“Statinsprotect against fulminant pneumococcal infection and cytolysintoxicity in a mouse model of sickle cell disease.”
By transplantation of bone marrow cells of either SCD mice or WT mice and One hundred days after transplantation, the sickle phenotype was confirmed by hemoglobin electrophoresis
(n = 26 and n = 24, respectively) or simvastatin (n = 27 and n = 32, respectively) following intranasal challenge with pneumococci;
*P = 0.023 versus SCD, **P = 0.0001 versus SCD
bacterial titers at 24 hours after challenge of SCD mice receiving mock
or simvastatin treatment.
(C) Blood and lung bacterial titers at 24 hours
after challenge of WT mice receiving mock or simvastatin treatment.
SCD mice were pretreated daily for 5 days with vehicle control (A–C) or simvastatin (D–F) and then challenged intranasally with pneumococci.
Lungs were harvested at 18 hours for histopathology (H&E
staining: A, B, D, and E) or apoptosis (C and F).