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Extension 能否經由抑制 Lipase 來治療青春痘 ?. Acne vulgaris 由 Propionibacterium acnes 引起. Lipase. Victoria Blue B. SA CK. MTT test for inhibition of P.acnes by SACCHACHITIN. Tyrosinase inhibition? 美白 ?. Melanoma cell line. CK. SA 0.1%. Melanin production. Conea repair. 眼角膜創傷治療
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Extension能否經由抑制 Lipase來治療青春痘? Acne vulgaris 由Propionibacterium acnes引起 Lipase
SA CK MTT test for inhibition of P.acnes by SACCHACHITIN
Melanoma cell line CK SA 0.1% Melanin production
Conea repair • 眼角膜創傷治療 • 不溶於水,如何成為眼藥水? • 微米化(直徑2 mm)
SEM SACCHACHITIN
SEM Micronized SACCHACHITIN
Fluorescein staining: Rabbit B Experimental Group Control Group
Experimental Group 200X 96hr Normal Conea Control Group 200X 96hr
SACCHACHITIN 之劑型 膜 微粒化懸浮液 軟膏
Tissue regeneration Cells 細胞 Growth Factors Biomaterials 生長因子 生物材料
References • 1.Su, C.H., C.H. Sun, S. W. Juan, C. H. Hu, W. T. Ke, M. T. Sheu 1997 • Fungal mycelia as the source of chitin and polysaccharides and their application as skin substitutes. Biomaterials 18:1169-1174 • 2. Su CH, Sun CS, Juan SW, Ho HO, Hu CH and Sheu MT 1999 • .Development of fungal mycelia as skin substitutes: Effects on the wound healing process. NTJM.(1):31-39. • 3. Su CH, Sun CS, Juan SW, Ho HO, Hu CH and Sheu MT 1999 • Development of fungal mycelia as skin substitutes: Effects on wound healing and fibroblast. Biomaterials.(20):61-68. • 4. Huang WS, Fang CL, Su CH , Lai WF , Chang WC, and Tsai YW 2001 • Cytotoxicity and immunogenecity of SACCHACHITIN and its mechanism of action on skin wound healing. J. Biomedical Research.(56):93-100. • 5. Hung WS, Lai WF, Leu B, Su CH, Fang CL, Tsai.YH 2004 • Effect of SACCHACHITIN on keratinocyte proliferation and the expressions of type I collagen and tissue-transglutaminase during skin wound healing. Journal Biomedical Material Research Part B: Applied Biomaterials.(70B):122-129. • 6. Su CH, Liu SH, Yu SY, Hsieh YL, Ho SO, Hu CH, Sheu MT 2005.Development of fungal mycelia as a skin substitute:Characterization of keratinocyte proliferation and matrix metalloproteinase expression during improvement in the wound-healing process. Journal of Biomedical Materials Research Part A.(72A):220-227.