DISORDERS OF THE ADRENOCORTICAL HORMONES. Dr. Ayisha Qureshi MBBS, Mphil. Hypoadrenalism- ADDISON’S DISEASE. ADDISON’S DISEASE. DEFINITION:
Dr. Ayisha Qureshi
Addison’s disease results from the inability of the adrenal cortices to produce the adrenal hormones & this is most frequently caused by the primary atrophy of adrenal cortex.
Patient cannot maintain normal blood glucose levels as no gluconeogenesis b/w meals
Nausea, vomiting, fever, hypotension
All metabolisms effected
Patient highly susceptible to the deteriorating effects of stress.
Even mild infections can lead to death
WHAT IS POMC & MSH?
Proopiomelanocortin (POMC) is a preprohormone which when cleaved causes the formation of:
(ACTH also has 1/30 as much activity of MSH & so its hypersecretion also causes Hyperpigmentation of the skin.)
Hypersecretion by the adrenal cortex causes a complex cascade of hormone effects called Cushing’s syndrome.
- Pituitary adenoma
- Ectopic ACTH syndrome
- Adrenal adenoma
- Adrenal carcinoma
When Cushing’s syndrome is secondary to excess secretion of ACTH by the anterior pituitary, it is called CUSHING’S DISEASE.
Occasionally, a small tumor of the zonaglomerulosa cells occurs & secretes large amounts of aldosterone; the resulting condition is called “Primary aldosteronism” or “ Conn’s disease”.
Usually, diagnosed by decreased plasma renin and increased aldosterone concentration.
A syndrome that is caused by occasional adrenocortical tumour that secretes excessive quantities of androgens.