drug body interactions n.
Download
Skip this Video
Download Presentation
Drug-Body Interactions

Loading in 2 Seconds...

play fullscreen
1 / 8

Drug-Body Interactions - PowerPoint PPT Presentation


  • 214 Views
  • Uploaded on

Drug-Body Interactions. Pharmacodynamics = The actions of drug on the body Pharmocokinetics= The actions of the body on the drug. Pharmacodynamic Principles. A. Types of Drug-Receptor interactions Agonists = Bind to, and activate the receptor.

loader
I am the owner, or an agent authorized to act on behalf of the owner, of the copyrighted work described.
capcha
Download Presentation

PowerPoint Slideshow about 'Drug-Body Interactions' - euphemia-cathy


Download Now An Image/Link below is provided (as is) to download presentation

Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author.While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server.


- - - - - - - - - - - - - - - - - - - - - - - - - - E N D - - - - - - - - - - - - - - - - - - - - - - - - - -
Presentation Transcript
drug body interactions
Drug-Body Interactions
  • Pharmacodynamics = The actions of drug on the body
  • Pharmocokinetics= The actions of the body on the drug
pharmacodynamic principles
Pharmacodynamic Principles

A. Types of Drug-Receptor interactions

  • Agonists = Bind to, and activate the receptor.

e.g.: Opening of an ion channel or activation of enzyme activity.

  • Antagonists = Prevent binding by other molecules

e.g.: Atropine, an acetylcholine receptor blocker

pharmacodynamics cont d
Pharmacodynamics (cont’d)

B. Duration of Drug Action

  • Effect of some drugs last only as long as they are bound to the receptor molecule
  • In other cases, the effect of drugs lasts until a new receptors are synthesized
pharmacodynamics cont d1
Pharmacodynamics (cont’d)

C. Receptors and Inert binding sites

Two principles:

  • The receptor must be selective in choosing ligands (drug molecules)
  • The receptor must change its function upon binding to cause the pharmacologic effect
pharmacokinetic principles
Pharmacokinetic Principles

Involve:

  • Absorption
  • Distribution
  • Permeation
  • Elimination
mechanisms of permeation
Mechanisms of Permeation
  • Aqueous diffusion- intestinal space, cytosol etc
  • Lipid diffusion – Most important limiting factor of drug permeation because of large number of lipid barriers that separates the compartments of our body
  • Special Carriers – peptides, amino acids, glucose
  • Endocytosis and Exocytosis – Large molecules are taken in by endocytosis. Many neurotransmitter substances are stored in membrane bound vesicles. Expulsion into the extracellular space is accomplished by exocytosis
antimicrobial peptides
Antimicrobial Peptides
  • Cationic peptides- plants, insects& others
  • Disrupt plasma membrane integrity
  • Megainin –from skin of frogs
  • Squalamine – from spiny dogfish shark
  • Protegrins – from pigs
antisense agents
Antisense Agents
  • Short segments of synthetic DNA
  • Selectively recognize and prevent pathogenic protein