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Effects of IFN-β on HIV-1 and SIVmac Fold Restriction in Untreated Conditions

This study explores the fold restriction impacts of IFN-β treatment versus untreated conditions on HIV-1 and SIVmac strains. We analyze the response of various MLV strains (B-MLV, N-MLV, NB-MLV) to treatment, quantifying the significant changes in viral restriction. The research emphasizes the role of immunomodulatory agents like CsA in enhancing the antiviral response. Results provide insights into viral behavior and potential therapeutic strategies against HIV in untreated settings.

estefani-perez
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Effects of IFN-β on HIV-1 and SIVmac Fold Restriction in Untreated Conditions

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  1. OMK cells A 8 30 25 6 20 Fold restriction (Untreated / IFN-β) 15 4 10 2 5 0 0 - + - + - + - + - + CsA B-MLV N-MLV NB-MLV SIVmac HIV-1 B 10 8 6 Fold restriction (Untreated / IFN-β) 4 2 0 HIV-1 SIVmac HIV SCA

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