NON-MENDELIAN GENETICS

1. NON-MENDELIAN GENETICS Definition Genetic interactions that do not follow complete dominance, are expressed together, or influence each other’s expression.

2. Incomplete Dominance Definition The phenotype of the heterozygote is intermediate between two homozygotes. Experimental Parental Monohybrid Cross   Design True-breeding red (R) flowered snapdragons were crossed with true-breeding white (r) flowered.

3. Incomplete Dominance F1 Generation Genotype:Rr Phenotype: Pink

4. Incomplete Dominance F2 Generation Genotypes: RR, Rr, rr Phenotypes: 1 Red, 2 Pink, 1 White

5. Incomplete Dominance Interpretation 1) Red snapdragons have two alleles of a gene for red pigment. Expression of both alleles gives the deep red color 2) White snapdragons have two alleles that specify "no pigment". Expression of both alleles gives no color 3) Pink snapdragons are heterozygous with one red allele; its expression results in only enough pigment molecules to make flowers pink.

6. Codominance Definition Two nonidentical alleles of a pair express two different phenotype in the heterozygote. Example 1) Blood groups are controlled by three alleles (multiple allele system). a) IA, IB, i 2) Possible Outcomes a) ii = O blood group b) IAIAor IAi = A blood group c) IBIBor IBi = B blood group d) IAIB = AB blood group (Codominance)

7. Codominance

8. Epistasis Definition Interaction of two or more gene pairs at different loci influence the same trait, but one allele has an overriding effect on the phenotype. Example 1) Hair color in Labrador dogs is determined by two sets of gene pairs. 2) Possible Alleles Quantity of Pigment (Melanin) Produced Black – B Brown – b Pigment (Melanin) Deposition Turned On – E Turned Off – e

9. Epistasis BlackBrownYellow BBEE BbEE bbEE BBee BBEe bbEe Bbee BbEe bbee 

10. Pleiotropy Definition A single gene affects more than one phenotype Example 1) White Mohan Tiger a) Same allele for absence of melanin production gives rise to crossed eyes. 2) Phenylketonuria (PKU) a) Same allele for toxic substances gives rise to light colored hair.

12. Penetrance (Expressivity) Definition Differing expressions of a gene. Example 1) Polydactyly

13. Penetrance (Expressivity)

14. Environmental Effects Definition The environment can affect the expression of a gene. Example 1) Himalayan rabbits a) Homozygous for ch allele coding for tyrosinase expressing melanin production b) Tyrosinase is not active above 33° C c) Hair appears light due to lack of melanin

16. Continuous Variation (Polygenic Inheritance) Definition Continuous range of small differences in a given trait among all the individuals of a population due to inheritance of multiple alleles that affect the same trait. Examples 1) Height   2) Eye color (4 Genes and 8 Alleles)

17. POLYGENIC INHERITANCE

18. EYE COLOR

19. Continuous Variation (Polygenic Inheritance) Eye ColorAllelesAlleles Light Blue aabbccdd 0 Medium Blue aabbccDd 1 Dark Blue aabbCcDd 2 Gray aaBbCcDd 3 Green AaBbCcDd 4 HazelAaBbCcDD 5 Light Brown AaBbCCDD 6 Medium Brown AaBBCCDD 7 Dark Brown AABBCCDD 8