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GABA B(1) fl/fl

A. D. C-fibers. A d -fibers. *. GABA B(1) fl/fl (n=15). 6. 15. *. SNS-GABA B(1) -/- (n=17). 4. 10. No. of spikes/s. No. of spikes/s. *. 2. 5. 0. 0. 6 12 24 48 96 192 384. 6 12 24 48 96 192 384. Displacement ( m m).

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GABA B(1) fl/fl

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  1. A D C-fibers Ad-fibers * GABAB(1)fl/fl (n=15) 6 15 * SNS-GABAB(1)-/- (n=17) 4 10 No. of spikes/s No. of spikes/s * 2 5 0 0 6 12 24 48 96 192 384 6 12 24 48 96 192 384 Displacement (mm) Displacement (mm) B E GABAB(1)fl/fl C-fibers GABAB(1)fl/fl Ad-fibers 12 20 * * 6 * 4 10 4 * * 15 * 2 * 8 * 2 * * 0 0 6 * No. of spikes/s 10 6 12 24 48 No. of spikes/s 6 12 24 48 4 * * 5 * * 2 Basal (n=15) Basal (n=21) * * CFA (n=17) CFA (n=20) 0 0 GABAB(1)fl/fl (n=21) 6 12 24 48 96 192 384 6 12 24 48 96 192 384 SNS-GABAB(1)-/- (n=20) Displacement (mm) Displacement (mm) C F SNS-GABAB(1)-/- C-fibers SNS-GABAB(1)-/- Ad-fibers 12 * 20 10 Basal (n=17) Basal (n=20) * 15 8 CFA (n=19) CFA (n=15) 6 No. of spikes/s 10 No. of spikes/s 4 5 2 0 0 6 12 24 48 96 192 384 6 12 24 48 96 192 384 Displacement (mm) Displacement (mm)

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