Hemodynamic disorders
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Hemodynamic Disorders. Fluid Homeostasis. Homeostasis is maintained by the opposing effects of: Vascular Hydrostatic Pressure and Plasma Colloid Osmotic Pressure. ASCITES . Edema. Pitting Edema. PERIORBITAL (RENAL). Pulmonary Edema.

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Fluid homeostasis
Fluid Homeostasis

Homeostasis is maintained by the opposing effects of:

  • Vascular Hydrostatic Pressure

    • and

  • Plasma Colloid Osmotic Pressure




Pitting edema
Pitting Edema


Pulmonary edema
Pulmonary Edema

  • The Lungs are typically 2-3 times normal weight

  • Cross sectioning causes an outpouring of frothy,

    sometimes blood-tinged fluid

  • It may interfere

    with pulmonary function

Hemodynamic disorders

Pulmonary Edema

the alveolar capillaries are engorged, and an intra-alveolar granular pink precipitate is seen

Brain edema
Brain Edema

The surface of the brain with cerebral edema demonstrates widened gyri with a flattened surface. The sulci are narrowed

Brain edema1
Brain Edema

Clinical CorrelationThe big problem is: There is no place for the fluid to go!

  • Herniation into the foramen magnum will kill

Effects of lipopolysaccharide septic shock
Effects of LipopolysaccharideSeptic Shock

LPS = lipopolysaccharide

TNF = tumor necrosis factor

IL = interleukin

NO = nitric oxide

PAF = platelet-activating factor

Hemodynamic disorders

ARDS/diffuse alveolar damage in shock

Some of the alveoli are collapsed; others are distended. Many contain dense proteinaceous debris, desquamated cells, and hyaline membranes

Hemodynamic disorders


lower field contains intact myocardium, while the upper field exhibits coagulation necrosis of myocardium. the hypoperfusion is greatest in the subendeocardium, which is perfused mainly in diastole.

Hemodynamic disorders


ATN in shock , extensive tubular isghaemia , note relative sparing of the glomeruli.