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The Blue People of Troublesome Creek. Daryl Hardnett Shaundra Mattox Termerion McCrary. In this lesson students will - . Understand basic principles of heredity Discuss microevolution and decide whether the blue people of Appalachia are “evolving”. K---W---L. Meet the Fugates….

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the blue people of troublesome creek

The Blue People of Troublesome Creek

Daryl Hardnett

Shaundra Mattox

Termerion McCrary

in this lesson students will
In this lesson students will -
  • Understand basic principles of heredity
  • Discuss microevolution and decide whether the blue people of Appalachia are “evolving”.
meet the fugates
Meet the Fugates…
  • Martin Fugate had methemoglobinemia, a condition that results in abnormal hemoglobin
meet the fugates1
Meet the Fugates
  • A symptom of this condition is “blue skin” which is due to the absence of the enzyme diaforase, a necessary enzyme that converts methemoglobin to hemoglobin
meet the fugates2
Meet the Fugates…
  • Martin married a carrier of the disease and they bore seven children; four of which were blue
  • The condition is inherited as a recessive trait and would appear most often in an inbred line
geographic isolation
Geographic Isolation…
  • The people of Troublesome Creek were isolated from the rest of the country. When the town was settled there were no roads, making it hard to get out and people tended to intermarry
  • One of Martin’s sons married his maternal aunt and 100 years later Benjy Fugate was born
  • As railroads and development swept through, the blue Fugates started moving out of Troublesome Creek and marrying other people
  • The inherited blue began to disappear as the recessive gene spread to families where it is unlikely to be paired to a similar gene
suggestions
Suggestions
  • Allele frequencies must change between generations
    • Drop West Nile
    • Do gene flow; another cup with alleles
  • Maps; History
  • Punnett Square
    • 2 cups: Male & Female cups