EpidemiologyEstimated new cases of AML in 2004: 12,000Median age: 65-70 yearsIncidence: 3.7 x 105<65 years of age: 1.8 x 105>65 years of age: 17.2 x 105Chance of having AMLFor a 50-yo: 1 in 50,000For a 70-yo: 1 in 7000. Acute myeloid leukemia. . AML in older patients. Poor response to chemotherapylow CR rate high treatment related morbidity and mortalityshort DFS and OSFactors contributing to poor outcomehost-relatedcomorbiditieslower tolerance to chemotherapydisease-relatedadve25
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