2003 2004 review of anticoagulants thrombolytics and anti platelet drugs l.
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2003-2004 Review of Anticoagulants, Thrombolytics and Anti-platelet Drugs. 1 April 2014 7:17 AM. Abciximab. Antiplatelet Anti-GPIIb/IIIa receptor antibody. Adalimumab. TNF inhibitor Anti-TNF antibody Used in rheumatoid arthritis. Allopurinol. Antigout Antineoplastic (supporting agent)

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2003 2004 review of anticoagulants thrombolytics and anti platelet drugs

2003-2004Review of Anticoagulants, Thrombolytics and Anti-platelet Drugs

1 April 20147:17 AM

abciximab
Abciximab
  • Antiplatelet
  • Anti-GPIIb/IIIa receptor antibody
adalimumab
Adalimumab
  • TNF inhibitor
  • Anti-TNF antibodyUsed in rheumatoid arthritis
allopurinol
Allopurinol
  • AntigoutAntineoplastic (supporting agent)
  • Folic acid analogueXanthine oxidase inhibitor
aminocaproic acid eaca
Aminocaproic acid (EACA)
  • Procoagulant
  • Inhibitor of plasminogen activation(decreases fibrinolysis)
anistreplase
Anistreplase
  • Thrombolytic
  • Streptokinase + plasminogen
aprotinin
Aprotinin
  • Procoagulant
  • Fibrinolytic inhibitorSerine protease inhibitor (“serpin”)Streptokinase inhibitor
argatroban
Argatroban
  • Anticoagulant
  • Direct thrombin inhibitor
aspirin acetylsalicylic acid asa
Aspirin(Acetylsalicylic acid, ASA)
  • NSAID (acetylsalicylate)Analgesic, Anti-inflammatoryAntipyretic, Antiplatelet
  • Irreversible cyclooxygenase inhibitor
atorvastatin
Atorvastatin
  • Antihyperlipidemic
  • HMG-CoA reductase inhibitor
auranofin
Auranofin
  • Disease modifyinganti-rheumatic drug (DMARD)
  • Gold saltOral
aurothioglucose
Aurothioglucose
  • Disease modifyinganti-rheumatic drug (DMARD)
  • Gold saltParenteral
balsalazide
Balsalazide
  • NSAID (salicylate)
  • Treatment of IBD
beclomethasone
Beclomethasone
  • AdrenocorticosteroidGlucocorticoid
  • Anti-inflammatory steroidInhaled
betamethasone
Betamethasone
  • AdrenocorticosteroidGlucocorticoid
  • Anti-inflammatory steroidNot by inhalation
bivalirudin
Bivalirudin
  • Anticoagulant
  • Direct thrombin inhibitor
bradykinin
Bradykinin
  • Inflammatory mediator
  • Plasma, hypotension, pain
budesonide
Budesonide
  • AdrenocorticosteroidGlucocorticoid
  • Anti-inflammatory steroidInhaled OR treatment of IBD
c3a c5a
C3a, C5a
  • Inflammatory mediators
  • Anaphylatoxins Low molecular weight complement cleavage products
celecoxib
Celecoxib
  • NSAIDAnti-inflammatory
  • Cyclooxygenase 2 (COX-2) inhibitor
cholestyramine
Cholestyramine
  • Antihyperlipidemic
  • Bile acid binding resin (BABR)
clofibrate
Clofibrate
  • Antihyperlipidemic
  • Lipoprotein lipase activator
clopidogrel
Clopidogrel
  • Antiplatelet
  • ADP receptor antagonist
colchicine
Colchicine
  • Antigout onlyAnti-inflammatory
  • Microtubule inhibitor
colestipol
Colestipol
  • Antihyperlipidemic
  • Bile acid binding resin (BABR)
cortisol hydrocortisone
Cortisol (Hydrocortisone)
  • AdrenocorticosteroidGlucocorticoid
  • Anti-inflammatory steroid
cromolyn sodium
Cromolyn sodium
  • Mast cell stabilizer
  • Inhibits release ofmast cell mediatorsUsed prophylactically in asthma
dalteparin
Dalteparin
  • Anticoagulant
  • LMW HeparinATIII activator
dexamethasone
Dexamethasone
  • AdrenocorticosteroidGlucocorticoidAntineoplasticAntiemetic
  • Anti-inflammatory steroidNot by inhalation
diflunisal
Diflunisal
  • NSAIDAnalgesic, Anti-inflammatory Antipyretic
  • Cyclooxygenase inhibitor
dipyridamole
Dipyridamole
  • Antiplatelet
  • Phosphodiesterase inhibitor(increases cAMP)
drotrecogin alfa activated protein c
Drotrecogin alfa(Activated Protein C)
  • Anticoagulant
  • Many actionsTreatment for septic shock
enoxaparin
Enoxaparin
  • Anticoagulant
  • LMW HeparinATIII activator
eptifibatide
Eptifibatide
  • Antiplatelet
  • GPIIb/IIIa antagonist
erythropoietin epo
Erythropoietin (EPO)
  • Cytokine
  • Primary regulator of RBC synthesis
etanercept
Etanercept
  • TNF inhibitor
  • Tumor necrosis factor receptor+ Fc portion of IgGUsed in rheumatoid arthritis
ezitimibe
Ezitimibe
  • Antihyperlipidemic
  • Cholesterol absorption inhibitor
fenofibrate
Fenofibrate
  • Antihyperlipidemic
  • Lipoprotein lipase activator
flunisolide
Flunisolide
  • AdrenocorticosteroidGlucocorticoid
  • Anti-inflammatory steroidInhaled
fluticasone
Fluticasone
  • AdrenocorticosteroidGlucocorticoid
  • Anti-inflammatory steroidInhaled
fluvastatin
Fluvastatin
  • Antihyperlipidemic
  • HMG-CoA Reductase Inhibitor
gemfibrozil
Gemfibrozil
  • Antihyperlipidemic
  • Lipoprotein lipase activator
gold salts
Gold salts

auranofin, aurothioglucose

  • Disease modifying anti-rheumatic drugs (DMARD)
granulocyte colony stimulating factor g csf
Granulocyte-Colony Stimulating Factor (G-CSF)
  • Cytokine
  • Granulocyte synthesis stimulator
granulocyte monocyte colony stimulating factor gm csf
Granulocyte/Monocyte-Colony Stimulating Factor (GM-CSF)
  • Cytokine
  • WBC (granulocytes and monocyte) synthesis stimulator
heparin
Heparin
  • Anticoagulant
  • ATIII activator
hirudin
Hirudin
  • Anticoagulant
  • Direct thrombin inhibitor(DTI)
histamine
Histamine
  • Inflammatory mediator
  • Stored in mast cells and basophils
hydrocortisone
Hydrocortisone
  • AdrenocorticosteroidGlucocorticoid
  • Anti-inflammatory steroid
hydroxychloroquine
Hydroxychloroquine
  • Disease modifyinganti-rheumatic drug (DMARD)
4 hydroxycoumarin
4-Hydroxycoumarin
  • Oral anticoagulant
  • Vitamin K synthesis inhibitor
ibuprofen
Ibuprofen
  • NSAIDAnalgesic, Anti-inflammatory Antipyretic
  • Reversible cyclooxygenase inhibitor
indomethacin
Indomethacin
  • NSAIDAnalgesic, Anti-inflammatory, Antipyretic
  • Cyclooxygenase inhibitorTocolyticUterine relaxant
infliximab
Infliximab
  • TNF inhibitor
  • Anti-TNF monoclonal antibodyTreatment of IBD
interferon alpha
Interferon alpha
  • Antiviral for hepatitisAntineoplasticCytokine
  • Anti-angiogenesis
interleukin 2
Interleukin 2
  • Cytokine Antineoplastic
interleukin 11
Interleukin 11
  • Cytokine Antineoplastic (supporting agent)
kallidin
Kallidin
  • Inflammatory mediator
  • Plasma, hypotension, pain
ketoprofen
Ketoprofen
  • NSAIDAnalgesic, Anti-inflammatory,Antipyretic
  • Cyclooxygenase inhibitor
lepirudin
Lepirudin
  • Anticoagulant
  • Direct thrombin inhibitor (DTI)
leukotriene b 4 ltb 4
Leukotriene B4 (LTB4)
  • Inflammatory mediator
  • Lipoxygenase productof arachidonate metabolismChemotactic
leukotrienes c 4 d 4 e 4 ltc 4 ltd 4 lte 4
Leukotrienes C4, D4, E4(LTC4,LTD4,LTE4)
  • Inflammatory mediators
  • Cysteinyl leukotrienesPeptidyl leukotrienesSRS-ALipoxygenase products ofarachidonate metabolism
lovastatin
Lovastatin
  • Antihyperlipidemic
  • HMG-CoA reductase inhibitor
meclofenamate
Meclofenamate
  • NSAIDAnalgesic, Anti-inflammatory, Antipyretic
  • Cyclooxygenase inhibitor
mesalamine 5 asa
Mesalamine(5-ASA)
  • NSAID (salicylate)
  • Treatment of IBD
methylprednisolone
Methylprednisolone
  • AdrenocorticosteroidGlucocorticoid
  • Anti-inflammatory steroidNot by inhalation
montelukast
Montelukast
  • Leukotriene inhibitor
  • LTR1 and LTD4 antagonistAsthma treatment
naproxen
Naproxen
  • NSAIDAnalgesic, Anti-inflammatory, Antipyretic
  • Cyclooxygenase inhibitor
nedocromil
Nedocromil
  • Mast cell stabilizer
  • Inhibits release of mast cell mediatorsUsed prophylactically in asthma
nicotinic acid
Nicotinic acid
  • Antihyperlipidemic
  • Inhibition of VLDL secretion (?)
non steroidal anti inflammatory drugs nsaids
Non-steroidalAnti-inflammatory Drugs (NSAIDs)
  • Analgesic, Anti-inflammatory, Antipyretic
  • Cyclooxygenase inhibitors
olsalazine
Olsalazine
  • NSAID (salicylate)
  • Treatment of IBD
phytonadione
Phytonadione
  • Vitamin K
  • Warfarin antagonist
piroxicam
Piroxicam
  • NSAIDAnalgesic, Anti-inflammatory, Antipyretic
  • Cyclooxygenase inhibitor
platelet activating factor paf
Platelet Activating Factor (PAF)
  • Inflammatory mediator
  • LipidHypotensive
pravastatin
Pravastatin
  • Antihyperlipidemic
  • HMG-CoA reductase inhibitor
prednisone
Prednisone
  • AdrenocorticosteroidGlucocorticoid Antineoplastic
  • Anti-inflammatoryNot by inhalation
probenecid
Probenecid
  • Uricosuric
  • Adjunct in penicillin therapy
probucol
Probucol
  • Antihyperlipidemic
  • LDL oxidation inhibitor
prostaglandin e 2 pge 2 dinoprostone dinoprost
Prostaglandin E2 (PGE2)Dinoprostone (Dinoprost)
  • Oxytocic prostaglandinInflammatory mediator
  • Cyclooxygenase product of arachidonate metabolismUterine stimulantCervical ripener
prostaglandin f 2 pgf 2
Prostaglandin F2 (PGF2)
  • Inflammatory mediator
  • Cyclooxygenase product of arachidonate metabolism
prostaglandin i 2 pgi 2
Prostaglandin I2 (PGI2)

Prostacyclin

  • Inflammatory mediator
  • Inhibits platelet aggregationCyclooxygenase product of arachidonate metabolism
protamine sulfate
Protamine Sulfate
  • Heparin antagonist
rofecoxib
Rofecoxib
  • NSAIDAnti-inflammatory
  • Cyclooxygenase 2 (COX-2) inhibitor
simvastatin
Simvastatin
  • Antihyperlipidemic
  • HMG-CoA reductase inhibitor
streptokinase
Streptokinase
  • Thrombolytic
rofecoxib87
Rofecoxib
  • NSAIDAnti-inflammatory
  • Cyclooxygenase 2 (COX-2) inhibitor
sulfasalazine
Sulfasalazine
  • Disease modifyinganti-rheumatic drug (DMARD)
  • Metabolized to sulfonamide+ salicylate (NSAID)Treatment of IBD
sulfinpyrazone
Sulfinpyrazone
  • Uricosuric
  • Anti-gout
sulindac
Sulindac
  • NSAIDAnalgesic, Anti-inflammatory, Antipyretic
  • Cyclooxygenase inhibitor
thrombopoietin
Thrombopoietin
  • Cytokine
  • Platelet synthesis stimulator
thromboxane a 2 txa 2
Thromboxane A2 (TXA2)
  • Autacoid
  • Promotes platelet aggregation Cyclooxygenase product of arachidonate metabolism
ticlopidine
Ticlopidine
  • Antiplatelet
  • ADP receptor antagonist
tissue plasminogen activators
Tissue plasminogen activators

alteplase, reteplase, tenecteplase

  • Thrombolytics
triamcinolone
Triamcinolone
  • AdrenocorticosteroidGlucocorticoid
  • Anti-inflammatory steroidInhaled
tumor necrosis factor
Tumor necrosis factor 
  • CytokineAntineoplastic
urokinase
Urokinase
  • Thrombolytic
warfarin
Warfarin
  • Anticoagulant
  • Vitamin K synthesis inhibitor
zafirlukast
Zafirlukast
  • Leukotriene inhibitor
  • LTR1 and LTD4 antagonistAsthma treatment
zileuton
Zileuton
  • Leukotriene inhibitor
  • 5-lipoxygenase inhibitorUsed in asthma