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2014 “Towards an HIV Cure” symposium Melbourne. The Role of a Public-Private Partnership in HIV Cure. Mike McCune, MD, PhD University of California, San Francisco. “Cure” Interventions that Can Be Used Around the World. The Goal To discover, develop, test, and distribute

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2014 towards an hiv cure symposium melbourne

2014 “Towards an HIV Cure” symposiumMelbourne

The Role of a Public-Private Partnership

in HIV Cure

Mike McCune, MD, PhD

University of California, San Francisco

cure interventions that can be used around the world
“Cure” Interventions that Can Be Used Around the World

The Goal

To discover, develop, test, and distribute

“cure” interventions that are:

Safe

Effective

Stable

Scalable

Affordable

hurdles to cross
Hurdles to cross

Science – Which mechanisms enable HIV persistence? Which can be interrupted?

People – How can we create and incentivize collaborative, multidisciplinary teams to test hypotheses?

Process – With what infrastructure, which cohorts, and which bioassay will potential “cures” be prioritized?

Distribution – If have a “cure” in hand, how can we assure its world-wide distribution?

the early stages of this process are done well by academic centers

Bench

The Early Stages of this Process Are Done Well by Academic Centers

Solo scientists

Single discipline

Discovery driven

Innovative

Clinic

Academic Center

the later stages are better performed by biotech pharma

Community

The Later Stages Are Better Performed by Biotech/Pharma

Multidisciplinary

teams

Practical solutions

Clinic

Profit oriented

Biotech/Pharma

a new model is needed to bring cures to resource poor settings

Bench

Community

A New Model Is Needed to Bring “Cures” to Resource-Poor Settings

Multidisciplinary

teams

Discovery driven

Practical solutions

Innovative

Clinic

Biotech/Pharma

Academic Center

public private partnership
Public-Private Partnership

Definition

An informal or formal arrangement between

one or more public sector entities

and

one or more private sector entities

To achieve a public health objective or to produce a health-related

product or service for the public good.

To share certain risks and to exchangeintellectual property,

financial, in-kind, and/or human resources in any mutually agreed

upon proportion.

public private partnership benefits
Public-Private Partnership: Benefits

Created to provide urgently needed therapies for

neglected diseases:

Malaria Leishmaniasis

Tuberculosis African trypanosomiasis

Dengue Chagas

Enable effective merger of strengths in academia,

industry, and non-governmental organizations

public private partnership ongoing efforts
Public-Private Partnership: Ongoing Efforts

• National Institutes of Health – “Cure Collaboratories”

• International AIDS Society

• Forum for Collaborative HIV Research

• American Foundation for AIDS Research

public private partnership the sunnylands initiative
Public-Private Partnership: The Sunnylands Initiative

HIV Cure Public-Private Partnership Initiative

November 2013: The Annenberg Foundation Trust at Sunnylands

convened an international group of leaders from science,

government, philanthropy, and industry to address issues

associated with HIV “cure.”

public private partnership the sunnylands initiative1
Public-Private Partnership: The Sunnylands Initiative

HIV Cure Public-Private Partnership Initiative

November 2013: The Annenberg Foundation Trust at Sunnylands

convened an international group of leaders from science,

government, philanthropy, and industry to address issues

associated with HIV “cure.”

Key question:

How can these groups work together

to most efficiently deliver safe, effective, and affordable

cure interventions for use around the world?

public private partnership the sunnylands initiative2
Public-Private Partnership: The Sunnylands Initiative

HIV Cure Public-Private Partnership Initiative

Resolved

• To identify, test, and distribute interventions that will, in

conjunction with effective antiretroviral therapy, lead to a

drug-free remission (or “cure”) in HIV-infected individuals.

• To work together to develop new pathways to amplify

existing HIV cure efforts.

• To overcome barriers to success through greater

collaboration.

public private partnership the sunnylands initiative3
Public-Private Partnership: The Sunnylands Initiative

HIV Cure Public-Private Partnership Initiative

Status

• Growing

• Designed to be inclusive

• Governance procedures being put into place

• Focused on three general topics…

hiv cure public private partnership initiative creation of a strategic plan
HIV Cure Public-Private Partnership Initiative: Creation of a Strategic Plan

Development of a “Roadmap:”

Highlighting priority areas of activity, identifying major

barriers to developing, producing, and distributing an HIV cure, and setting forth major milestones associated with scientific, clinical, regulatory, production, and distribution/access efforts that will guide stakeholder efforts over the

next 20 years.

hiv cure public private partnership initiative quantifying the reservoir
HIV Cure Public-Private Partnership Initiative: Quantifying the Reservoir

Discovery and standardization of a biomarker:

Focused on the development and standardization of

novel methods for quantifying HIV persistence that are:

• capable of quantifying the total body burden of SIV in

relevant long-term treated nonhuman primates

• predictive of time to virologic rebound during carefully-

monitored analytic treatment interruptions

• blood-based

• high throughput

• applicable for routine clinical settings

hiv cure public private partnership initiative making cures affordable
HIV Cure Public-Private Partnership Initiative: Making “Cures” Affordable

Establishment of a business case:

What are the financial and societal implications of achieving a “cure” for HIV disease that is accessible in both high and low resource settings?

What are the incentives for entities within and across sectors to form collaborative bonds with one another to reach this goal?

public private partnership the sunnylands initiative4
Public-Private Partnership: The Sunnylands Initiative

HIV Cure Public-Private Partnership Initiative

For more information

Ellen LaPointe, JD, is serving as the Project Director for the initiative

and can be reached atellenlapointe@gmail.com.