1 / 11

Part II Lecture on Ig & TCR Genes 3 rd November 2011

Part II Lecture on Ig & TCR Genes 3 rd November 2011. by Mike Clark, PhD Reader in Therapeutic and Molecular Immunology Department of Pathology Division of Immunology Cambridge University UK CB2 1QP www.antibody.me.uk. Mammalian Antibody Classes.

emerald-orr
Download Presentation

Part II Lecture on Ig & TCR Genes 3 rd November 2011

An Image/Link below is provided (as is) to download presentation Download Policy: Content on the Website is provided to you AS IS for your information and personal use and may not be sold / licensed / shared on other websites without getting consent from its author. Content is provided to you AS IS for your information and personal use only. Download presentation by click this link. While downloading, if for some reason you are not able to download a presentation, the publisher may have deleted the file from their server. During download, if you can't get a presentation, the file might be deleted by the publisher.

E N D

Presentation Transcript

  1. Part II Lecture on Ig & TCR Genes3rd November 2011 by Mike Clark, PhD Reader in Therapeutic and Molecular Immunology Department of Pathology Division of Immunology Cambridge University UK CB2 1QP www.antibody.me.uk

  2. Mammalian Antibody Classes • Antibodies are classed according to the type of immunoglobulin heavy chain • In addition each antibody class can have either κ (kappa) or λ (lambda) immunoglobulin light chains • In mammals we recognise the following classes and chains • IgM μ (mu) • IgD δ (delta) • IgG γ (gamma) • IgA α (alpha) • IgE ε (epsilon)

  3. Schematic view of IgG domains

  4. Kabat database variability of VH sequences Mouse VH Human VH

  5. Lysozyme CDR regions Antibody Fv

  6. Simplified view of a light chain locus

  7. Lymphocyte specific Enzymes used for Ig Gene repertoire AID Activation induced cytidine deaminase Class switching and somatic mutation RAG Recombination activation genes (RAG1 and RAG2) Segmental recombination

  8. AID LEUCINE REPEAT RECEPTORS Jawless fish Segmental recombination RAG IMMUNOGLOBULINS Somatic mutation Gene Rearrangement [V-(D)-J joining] Jawed fish Amphibians Class switch Gene Conversion Birds Marsupials Placentals Primates Slide courtesy of Michael Neuberger

More Related