Utilizing Peanut ( arachis hypogaea ) extract as a potential source of Resveratrol in activating SIRT1 gene. Chapter 1 Problem and its setting. INTRODUCTION
Peanut (Arachi hypogaea)
Extraction of resveratrol from Peanut (Arachi hypogaea)
Activating SIRT 1 gene through resveratrol
Potential source in killing cancer cells
Peanut- is a species in the legume. The cultivated peanut was probably first domestricated in the valleys of Peru. It is an annual herbaceous plant growing 30 to 50 cm tall. The leaves are popposite, pinnate with four leaflets, each leaflet 1 to 7 cm long and 1 to 3 cm broad. The flowers are a typical peaflower. In shape, 2 to 4 cm across, yellow with reddish veining. After pollination, the fruit develops into a legume 3 to 7 cm long, containing 1 to 4 seeds, which forces its way underground a mature. Hypogaea means “under the earth”. Peanut has only occasionally been grown in Northern States due to its warm temperature requirement. Use of poorly adapted varieties and improper production practices usually resulted in low yields and poor quality nuts. However, peanut could be an alternative cash crop to soybean, corn, potato or fieldbean.
Resveratrol- essentially, the resveratrol compound is classified in a pamily that’s known as polyphenols. In small amounts, resveratrol can be found naturally in grapes, some green teas and even peanuts. It is also the main ingredient that gives red wine natural anti-aging propertie.
SIRT 1 gene- or “skinny gene” assists with weight loss by inhibiting food storage and increasing fat metabolism. By causing the body to store fewer fat cells, SIRT 1 can also slow the aging process by reducing t5he risk of age- related diseases and health threats, including heart attack and stroke, diabetes, arthritis and osteoporosis. These conditions have all been linked to an excess amount of fat cells in the sky.
Cancer- is the general name for a more than 100 diseases in which cells in a part of the body begin to grow out of control. Although there are many kinds of cancer, they can start because abnormal cells grow out of control. Untreated cancers can cause serious illness and even death.
For the extraction of resveratrol from the peanut (Arachishypogaea)extract the following materials that will be used: Rotavap for extracting the peanut, ethanol for separating resveratrol from the peanut (arachishypogaea) extract, large metal containers (extractors)where the plant source will be placed, peanut, laboratory test equipment for plants, column of silica, vacuum dryer to remove alcohol.
Collection of Peanut Sample
Analysis of the Results
Extraction of Peanut
Separating Resveratrol Extract
Treatment to Cancer cells
Activating SIRT1 gene
JOUE L. VALLENTE