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DERMATOLOGIC MANIFESTATIONS OF GASTROINTESTINAL DISEASES

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DERMATOLOGIC MANIFESTATIONS OF GASTROINTESTINAL DISEASES

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    1. DERMATOLOGIC MANIFESTATIONS OF GASTROINTESTINAL DISEASES Micheline Maamari Chalouhi,MD

    2.

    4. ESOPHAGUS Dysphagia 1-Diseases extending to the esophagus 2-connective tissue diseases 3-cancer

    5. Candida

    6. Pemphigus vulgaris Autoimmune Sore throat, dysphagia

    7. Systemic sclerosis Crest Lower 2/3 90% Premature fullness,reflux dysphagia,abdominal pain

    8. Plummer vinson (paterson kelly) syndrome Postcricoidal web Koilonychia Sore tongue angular stomatitis Iron deficiency

    9. cancer Tylosis

    10. Gastrointestinal Bleed Hereditary hemorrhagic telangiectasias AD Vascular dilatation:oral, nasal, GI Epitaxis(1) Severe GI bleed (2) first decade

    11. Gastrointestinal Bleed Ehlers-Danlos Type 3 & 4 collagen defect

    12. Gastrointestinal Bleed Pseudoxathoma elasticum

    13. Gastrointestinal Bleed Kaposi sarcoma(HHV8) Endothelial & lymphoreticular cells GI: 50-80% cutaneous 100% oral stomach,esophagus, SI

    14. Polyposis Gardner’s syndrome AD(defect ch 5) Epidermoid cysts,fibromas, lipomas,osteomas adenomatous polyps colon Carcinoma

    15. POLYPOSIS Canada cronkhite syndrome Macular hyperpigmentation Alopecia(rapid onset) Nail atrophy (onycholysis, triangular deformity)

    16. POLYPOSIS Cowden disease AD Skin tags,acral keratoses,oral fibroma Breast,thyroid,cervical,colon cancer

    17. POLYPOSIS Muir-torre Sebaceous gland tumors Visceral malignancies(colon,kidney,uterus…)

    18. POLYPOSIS Peutz-jegher’s syndrome AD Hamartomatous polyps(jejunum) Lips,buccal mucosa,gingiva,.. Ovary,thyroid,cervix CA

    19. INFLAMATORY BOWEL DISEASES pyoderma gangrenosum 50%PG have UC 10% UC have PG Severity & extent of ulceration are Linked to the activity of the disease

    20. INFLAMATORY BOWEL DISEASES Granulomas

    21. INFLAMATORY BOWEL DISEASES Erythema nodosum

    22. INFLAMATORY BOWEL DISEASES Aphtous ulcers

    23. PANCREATITIS acute

    24. pancreatic fat necrosis

    25. Signs of specific GI tumors Stomach Pernicious anemia Vitiligo Alopecia areata

    26. Signs of specific GI tumors Small bowel Carcinoid Release of serotonin & bradykinin Hepatic metastasis Paroxysmal Telangiectasia, plethora….

    27. Signs of specific GI tumors Large bowel Paget Intense pruritis Glandular adnexal ca or regional internal ca

    28. Signs of specific GI tumors Glucagonoma APUD Necrolytic migratory erythema

    29. Paraneoplastic signs Dry skin Eczema craquele malabsorption

    30. Paraneoplastic signs Dermatomyositis Early sign Life saving

    31. Paraneoplastic signs Acanthosis nigricans

    32. Paraneoplastic signs sister Mary Joseph nodule

    33. Paraneoplastic signs Lesser trelat

    34. Thank you……..

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