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Auditory Physiology 2

Auditory Physiology 2. PSY 295 – Sensation & Perception Christopher DiMattina , PhD. Hearing. Auditory nerve. The auditory nerve . The auditory nerve receives input from hair cells We characterize auditory nerve fibers by their responses to pure tone stimuli. Auditory nerve fibers.

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Auditory Physiology 2

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  1. Auditory Physiology 2 PSY 295 – Sensation & Perception Christopher DiMattina, PhD

  2. Hearing PSY 295 - Grinnell College - Fall 2012

  3. Auditory nerve PSY 295 - Grinnell College - Fall 2012

  4. The auditory nerve • The auditory nerve receives input from hair cells • We characterize auditory nerve fibers by their responses to pure tone stimuli PSY 295 - Grinnell College - Fall 2012

  5. Auditory nerve fibers • Tone frequency which increases the neuron’s firing rate at lowest intensity is the characteristic frequency (CF) PSY 295 - Grinnell College - Fall 2012

  6. Nonlinear interactions • Two-tone suppression – playing a second tone of a slightly different frequency can suppress responses to a CF tone • Arises from mechanics of basilar membrane PSY 295 - Grinnell College - Fall 2012

  7. Rate-intensity functions • Auditory nerve fibers increase their firing rate as a function of CF tone level • High spontaneous rate fibers and low spontaneous rate fibers PSY 295 - Grinnell College - Fall 2012

  8. Temporal code for frequency • Auditory nerve fibers phase-lock to tones at lower frequencies • Phase locking becomes inconsistent at higher frequencies due to ANF refractory period PSY 295 - Grinnell College - Fall 2012

  9. Volley principle • Even if individual neurons cannot lock, their total responses can lock to provide a temporal code for sound PSY 295 - Grinnell College - Fall 2012

  10. Central auditory system PSY 295 - Grinnell College - Fall 2012

  11. Central auditory pathway PSY 295 - Grinnell College - Fall 2012

  12. Cochlear nucleus • Receives inputs from the auditory nerve • Diverse cell types with variety of response properties • Some cells tuned to the location of spectral notches, which are an important cue for vertical sound localization PSY 295 - Grinnell College - Fall 2012

  13. Superior olive • First stage where inputs from both ears come together • Important to integrate binaural inputs for sound localization PSY 295 - Grinnell College - Fall 2012

  14. Sound localization PSY 295 - Grinnell College - Fall 2012

  15. Inferior colliculus PSY 295 - Grinnell College - Fall 2012

  16. Inferior colliculus • Complex auditory processing • Neurons sensitive to complex sounds like amplitude-modulated and frequency-modulated stimuli • Performs complex integration of spectral energy PSY 295 - Grinnell College - Fall 2012

  17. Thalamus • Medial geniculate body of thalamus exhibits tonotopic organization and provides input to primary auditory cortex PSY 295 - Grinnell College - Fall 2012

  18. Auditory cortex PSY 295 - Grinnell College - Fall 2012

  19. Tonotopic organization in A1 PSY 295 - Grinnell College - Fall 2012

  20. Auditory cortex responses • Neurons sensitive to more complex spectral-temporal combinations of sound • Two tone pips at specific time delay and frequency difference PSY 295 - Grinnell College - Fall 2012

  21. Auditory cortex • Cells sensitive to musical pitch PSY 295 - Grinnell College - Fall 2012

  22. Hearing loss PSY 295 - Grinnell College - Fall 2012

  23. Hearing loss • 30 million Americans suffer some form of hearing loss • Typically this means elevated thresholds • Many kinds of hearing loss PSY 295 - Grinnell College - Fall 2012

  24. Conductive hearing loss • Middle ear bones are impaired • Middle ear fills with mucus during inner ear infections (otitis media) • Otosclerosis– abnormal bone growths PSY 295 - Grinnell College - Fall 2012

  25. Sensorineural hearing loss • Damage to hair cells or auditory nerve • Exposure to loud sounds • Ototoxic drugs PSY 295 - Grinnell College - Fall 2012

  26. Environmental noise and hearing PSY 295 - Grinnell College - Fall 2012

  27. Hearing aids amplify and compress sounds PSY 295 - Grinnell College - Fall 2012

  28. Cochlear implants PSY 295 - Grinnell College - Fall 2012

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