Aerobic Non-Spore Forming Gram-Positive Bacilli. Corynebacterium. Gram Positive Bacilli. Gram positive rods. Spore forming. Non spore forming. Aerobic. Anaerobic. Corynebacterium. Clostridium spp. Bacillus spp. Species of Corynebacteria. Corynebacterium diphtheriae.
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Gram positive rods
Non spore forming
Normal flora of RT, urethra, vagina, Skin
ØLipid-rich cell wall contains meso-diaminopimelic acid, arabino-galactan polymers, and short-chain mycolic acids
Acute, Toxin mediated
Recovery or complication & death (if more toxin absorbed)
Childhood disease affect upper respiratory tract
Respiratory obstruction due to extensive membrane formation
Transmitted by droplet infection
2-6 days I.P.
Sore throat, Pharyngitis
2-3 days, Bluish white adherent pseudo membrane
Phospholipase D: increse vascular permeability and promote spread of organism
C. jeikeium, and C. urealyticum are
characteristically resistant to
penicillin and other -lactam
drugs, and uniformly vancomycin
To confirm the clinical manifestation
The colonies of C. diphtheriae are small, granular, grey, smooth, and creamy with irregular edges
Lines of precipitations
Positive Elek’s Test