Aerobic Non-Spore Forming Gram-Positive Bacilli. Corynebacterium. Gram Positive Bacilli. Gram positive rods. Spore forming. Non spore forming. Aerobic. Anaerobic. Corynebacterium. Clostridium spp. Bacillus spp. Species of Corynebacteria. Corynebacterium diphtheriae.
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Gram positive rods
Non spore forming
Normal flora of RT, urethra, vagina, Skin
Cased by C. diphtheriae
Acute, Toxin mediated
Recovery or complication & death (if more toxin absorbed)
Childhood disease affect upper respiratory tract
Respiratory obstruction due to extensive membrane formation
Transmitted by droplet infection
2-6 days I.P.
Sore throat, Pharyngitis
2-3 days, Bluish white adherent pseudo membrane
Phospholipase D: increse vascular permeability and promote spread of organism
C. jeikeium, and C. urealyticum are
characteristically resistant to
penicillin and other -lactam
drugs, and uniformly vancomycin
To confirm the clinical manifestation
Laboratory diagnosis of case results
Lines of precipitations
Positive Elek’s Test