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Enzyme Inhibition and Regulation . CHEM&131 Spring, 2012 Nazrawie Tesfay Nafkot Nurga Senait Habtu. Enzyme Inhibition. Enzyme inhibitors Are a molecule that binds with the active site of an enzyme to decreases its activity.

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enzyme inhibition and regulation

Enzyme Inhibition and Regulation

CHEM&131

Spring, 2012

Nazrawie Tesfay

Nafkot Nurga

Senait Habtu

enzyme inhibition
Enzyme Inhibition
  • Enzyme inhibitors
  • Are a molecule that binds with the active site of an enzyme to decreases its activity.
  • It stop the substrate from binding to the enzyme’s active site
  • It can be reversible or irreversible.
competitive inhibition
Competitive Inhibition
  • It has the same shape and chemical structure with the normal substrate.
  • It compete with the normal substrate for the active site of the enzyme.
  • It prevent the substrate from reacting with the enzyme.
  • No reaction occurs.
non competitive
Non-Competitive
  • It does not compete with the substrate for the active site of the enzyme.
  • It bind to the other site of the enzyme called Allosteric site.
  • It causes the enzyme change its shape temporarily and makes it nonfunctional.
irreversible inhibition
Irreversible inhibition
  • It is a process of restraining the enzyme from functioning by changing its chemical structure.
  • The inhibitor forms covalent bond with the enzyme’s active site.
allosteric enzymes
Allosteric Enzymes
  • Have two receptor sites
  • An active site for substrates
  • Allosteric site for Modulators and activators
enzyme regulation
Enzyme Regulation
  • Enzyme regulation is the way of controlling the rate of reaction of the enzyme by modulator.
  • Enzyme regulation by inhibition can happen on the active site or allosteric site but modulation happens only on the allosteric site.
  • Enzyme regulation involves not only inhibition but also activation of the enzyme’s activity.
modulator
Modulator
  • modulator is a molecule that binds to the allosteric site of the allosteric enzyme and alters the active site’s shape.
  • Is more selective and more potent than the active site inhibition.
types of modulators
Types of modulators

Negative modulators:

  • Are types of modulators that bind to the allosteric site and change the shape of the active site, so the substrate will not be able to bind to the active site.
  • Are non competitive inhibitors.

Positive modulators:

  • Are types of modulators that bind to the allosteric site and change the shape of the active site, so the substrate will be able to bind to the active site.
  • they activate the active site of the allosteric enzyme and we call them Activators.
activator
Activator
  • Activator is molecule that bind to the allosteric site and it increase the enzyme's’ activity.
  • Activators are inorganic compounds.
  • Are modulators.
source
Source
  • Enzyme Regulators." Enzyme Regulators. Web. 07 June 2012. <http://www.elmhurst.edu/~chm/vchembook/573regulate.html>.
  • "Google Books." Google Books. Web. 07 June 2012. <http://books.google.com/>.
  • "Allosteric Activation." Allosteric Activation. Web. 07 June 2012. <http://course1.winona.edu/sberg/animtns/allostan.htm>.
  • "Biosphere." Biosphere. Web. 07 June 2012. <http://faithbiology.edublogs.org/category/uncategorized/page/2/>.