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Sec61/SecY Protein review. Sec61 protein is important for the movement of proteins across the cell membrane? A signal sequence guides the protein to the Sec61 protein? A plug model was put into play by this paper?. Lipid Membrane. More characteristics.

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sec61 secy protein review
Sec61/SecY Protein review
  • Sec61 protein is important for the movement of proteins across the cell membrane?
  • A signal sequence guides the protein to the Sec61 protein?
  • A plug model was put into play by this paper?
more characteristics
More characteristics
  • Driving Force of formation of lipid bilayer are Hydrophobic Interactions
kinds of lipids in membrane
Kinds of lipids in membrane
  • Phospholipids
  • Glycolipids
  • cholesterol
phospholipids
Phospholipids
  • PE- phosphatidyl ethanolamine
  • PC- phosphatidyl choline
  • SM- sphingomyleine
  • PS- phosphatidyl serine

Can serve as different markers for cell

k channel
K+ Channel
  • Selective filter for moving potassium out of the cell
  • Has four identical transmembrane subunits
  • Each subunit has 2 transmembrane helices and a third shorter helix called the pore helix
  • These subunits form a central pore
slide10
Channel tilts outwards
  • Has a loop that forms in channel and is going to make the selectivity filter, which will only allow K+ out
  • Filter formed by carbonyl oxygens of the peptide backbone
slide11
K+ is 1.95 A NA+ is 0.95 A
  • In the cell potassium will be hydrated with water and so will sodium
  • Bonding between these elements and water will be a specific length
  • Water needs to be shed in order for K+ to go through
slide12
Carbonyl oxygen will act as the surrogate water
  • The dehydration of the ion takes energy but it is immediately made up by interactions with carbonyl oxygen
  • Na is too small for this mechanism and therefore is not transported out
porin
Porin
  • Made by up and down barrel
  • Either 16 are 18 beta strands make up the porin
  • Porin channel has a loop region in the middle of it which will act as a selective filter. 8 A in diameter
  • Only certain small molecules will be able to transverse the membrane
bacteriarhodopsin
Bacteriarhodopsin
  • 7 transmembrane alpha helices
  • This protein is used for transforming light to chemical energy
  • Proton pump
retinol
Retinol
  • Bound in the pocket of the protein
  • Undergoes isomerization when light hits it from trans to cis
  • Bound covalently to lysine 216
slide22
Light at a certain wavelength cause change from trans to cis of retinal
  • Then Asp transfers proton to schiff base
  • This proton is then transferred to Asp 85 and then out to the extracellular space
result
Result
  • Form an electrochemical gradient which is important for bacteria survival
  • Use for generation of energy
photosynthetic reaction center
Photosynthetic Reaction Center
  • L, H, M and cytochrome subunits
  • L and M subunits each have 5 hydrophobic transmembrane helices
  • H subunit has one transmembrane helice
what is taking place
What is taking place
  • Transfer of light to generate energy
  • Players in the reaction must be arranged in a way that ensures the forward movement of the reaction
  • Photons absorbed by chlorophylls